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PhysioMimix™ OOC Microphysiological Systems

PhysioMimix™ OOC system with plates

Transforming the way human-relevant preclinical data is generated


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Transform the way you generate human-relevant data using our PhysioMimix OOC range of single- and multi-organ microphysiological systems (commonly known as Organ-on-a-Chip).

Preclinical drug discovery and development workflows urgently require innovative models that reliably predict drug effects to reduce drug attrition rates.

Our systems allow you to recreate a test environment that accurately represents the human body so that you can generate clinically-translatable data.

By improving the in vivo predictivity of in vitro data, PhysioMimix OOC helps companies like yours to develop safe and efficacious therapeutics, faster and more cost-effectively, while reducing the dependence on animal usage.

How translatable is your data?

Human-relevant data generated by the PhysioMimix OOC complements that derived using entrenched 2D cell culture and animal studies to support more confident decision-making across many drug discovery stages from target discovery right through to preclinical development. ​

Limitations of current techniques

  • In vitro 2D cell culture models lack physiological relevance
  • In vivo animal models lack human relevance; studies are slow, expensive, and ethically undesirable
  • Inter-species differences limit the suitability of animals for testing human-specific drug modalities

Advancements with PhysioMimix

  • Faithfully recapitulate the phenotype and function of human organs and tissues in vitro
  • Addresses the relevance limitations of standard preclinical models to validate or query their results
  • Provides a rapid, usable, cost-effective and more human-relevant alternative

What’s required to accurately model and measure human physiology?

Human body graphic showing internal organs

PhysioMimix OOC enables​:

  • the co-culturing of human cells to faithfully recreate human organs and tissues​
  • perfused scaffolds to promote 3D organ model formation​
  • compatibility with inserts for apical and basolateral tissue growth to recreate a biological barrier
  • recirculating fluidic flow delivering biomechanical stimulus, oxygen, and nutrients ​
  • adjustable inter- and intra-organ flow rates to enhance physiological relevance​
  • viability, function, and phenotype to be maintained over many weeks​ to enable longer-term chronic disease and dosing studies
  • deep mechanistic insights via large sampling volume (up to 1 mL) and individual microtissue analysis
  • modeling of the immune system via the inclusion of circulating immune cells

Preclinical toolbox comparison

How does OOC compare to conventional preclinical approaches?

In vitro 2D cell cultureIn vitro 3D spheroidIn vivo animal modelsOrgan-on-a-chip
Human relevance
Complex 3D organs and tissues
(Blood)/Flow perfusion
Immune system
Longevity< 7 days< 7 days> 4 weeks~ 4 weeks
Acute and Chronic dosing
Throughput
Ease of adoption
Cost$$$$$$$
Time to resultFASTFASTSLOWFAST
Data contentLOWMEDIUMHIGHHIGH

Which of our microphysiological systems meets your needs?


PhysioMimix Single-organ System image

PhysioMimix Single-organ System


Enables the creation of in vitro 3D single-organ models to provide fast, accurate, and clinically translatable human data.​

Generate Liver-on-a-chip models that mimic the human liver microarchitecture using the PhysioMimix Liver plate.

Generate barrier models (such as Gut- or Lung-on-a-chip) on Transwell® inserts using the PhysioMimix Barrier plate.

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PhysioMimix Multi-organ System​ image

PhysioMimix Multi-organ System​


Providing additional functionality, the multi-organ system enables you to interconnect our liver model with an additional organ, such as the gut or lung, using the PhysioMimix Dual-organ plate.

By mimicking how organs interact and communicate as part of a complex system, you benefit from a deeper human-specific mechanistic understanding of disease states and drug behavior.

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Customer feedback

The CN Bio MPS system allows hepatic cultures to be grown for weeks with low signs of cytotoxicity or hepatocytes de-differentiation detectable; CN Bio has developed an efficient proprietary protocol to model NASH that shows really high homology with murine models of NASH in terms of transcriptome, inflammatory profiling and pathophysiological events crucial for disease progression

The hepatic co-cultures of hepatocytes, Kupffer and stellate cells that I have tested also behave as expected in vivo with regards to intracellular signalling pathways (such as TGFβ signalling) thus allowing the modeling of chronic liver disease pathophysiology.

I think that the PhysioMimix OOC system will become a “must-have” piece of equipment for labs focussing on liver pathophysiology and tissue-to-tissue interactions.

Michele Vacca, MD PhD

Clinician Research Associate at the Institute of Metabolic Science, University of Cambridge

View more PhysioMimix OOC reviews on SelectScience

Michele Vacca, MD PhD

Application areas

Disease modeling cell image

Disease modeling

Our models functionally mimic the organ and give a realistic expression of disease phenotypes for improved efficacy assessments

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Safety toxicology cell image

Safety toxicology

By closely mimicking in vivo function, our models better predict drug safety to support and accelerate drug development.

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ADME cell image

ADME

Single- and multi-organ models closely predict human in vivo pharmacokinetics for informed insights into the body’s effect on drugs.

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Why choose PhysioMimix?

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Lab benchtop ready

Portable and compact

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Quick to set up

Get operational in less than an hour

icon for user friendly

User friendly

Program and start a run in less than 1 minute

icon for Highly compatible

Highly compatible

Use with existing equipment

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Open-well design

Supports your 2D to 3D cell culture transition

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Real-time monitoring

Remove samples for analysis, experiments continue to run

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“Set-and-Run” Perfusion

Long-term automated experiments with minimal user input

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Tissues and cells

Compatible with a range of pre-formed tissues and cell types for ultimate flexibility

Icon for Multi-organ compatible

Multi-organ compatible

Connect two organs via microfluidics to study cross-talk

Featured resources

Articles

Hype or Hope |

Hype or hope – microphysiological systems?

Podcasts

My project copy 1 3 |

Opinionated Science: What is Body-on-a-Chip Technology

Webinars

web s2e1 |

The Rhythm of Life

Speak to our experts

Speak directly with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system January 17, 2023
  • The U.S. FDA Modernization Act 2.0. Now the animal testing mandate is removed, learn what can be embraced in its place. January 9, 2023
  • CN Bio appoints Dr Paul Brooks as Chief Executive Officer December 19, 2022

Upcoming events

MPS World Summit 2023 June 26-30, 2023

SLAS Europe 2023 May 22-26, 2023

SLAS2023 February 25 - March 1, 2023