Transforming the way human-relevant preclinical data is generated
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Transform the way you generate human-relevant data using our PhysioMimix OOC range of single- and multi-organ microphysiological systems (commonly known as Organ-on-a-Chip).
Preclinical drug discovery and development workflows urgently require innovative models that reliably predict drug effects to reduce drug attrition rates.
Our systems allow you to recreate a test environment that accurately represents the human body so that you can generate clinically-translatable data.
By improving the in vivo predictivity of in vitro data, PhysioMimix OOC helps companies like yours to develop safe and efficacious therapeutics, faster and more cost-effectively, while reducing the dependence on animal usage.
How translatable is your data?
Human-relevant data generated by the PhysioMimix OOC complements that derived using entrenched 2D cell culture and animal studies to support more confident decision-making across many drug discovery stages from target discovery right through to preclinical development.
Limitations of current techniques
- In vitro 2D cell culture models lack physiological relevance
- In vivo animal models lack human relevance; studies are slow, expensive, and ethically undesirable
- Inter-species differences limit the suitability of animals for testing human-specific drug modalities
Advancements with PhysioMimix
- Faithfully recapitulate the phenotype and function of human organs and tissues in vitro
- Addresses the relevance limitations of standard preclinical models to validate or query their results
- Provides a rapid, usable, cost-effective and more human-relevant alternative
What’s required to accurately model and measure human physiology?
PhysioMimix OOC enables:
- the co-culturing of human cells to faithfully recreate human organs and tissues
- perfused scaffolds to promote 3D organ model formation
- compatibility with inserts for apical and basolateral tissue growth to recreate a biological barrier
- recirculating fluidic flow delivering biomechanical stimulus, oxygen, and nutrients
- adjustable inter- and intra-organ flow rates to enhance physiological relevance
- viability, function, and phenotype to be maintained over many weeks to enable longer-term chronic disease and dosing studies
- deep mechanistic insights via large sampling volume (up to 1 mL) and individual microtissue analysis
- modeling of the immune system via the inclusion of circulating immune cells
Preclinical toolbox comparison
How does OOC compare to conventional preclinical approaches?
|In vitro 2D cell culture||In vitro 3D spheroid||In vivo animal models||Organ-on-a-chip|
|Complex 3D organs and tissues|
|Longevity||< 7 days||< 7 days||> 4 weeks||~ 4 weeks|
|Acute and Chronic dosing|
|Ease of adoption|
|Time to result||FAST||FAST||SLOW||FAST|
Which of our microphysiological systems meets your needs?
PhysioMimix Single-organ System
Enables the creation of in vitro 3D single-organ models to provide fast, accurate, and clinically translatable human data.
Generate Liver-on-a-chip models that mimic the human liver microarchitecture using the PhysioMimix Liver plate.
Generate barrier models (such as Gut- or Lung-on-a-chip) on Transwell® inserts using the PhysioMimix Barrier plate.
PhysioMimix Multi-organ System
Providing additional functionality, the multi-organ system enables you to interconnect our liver model with an additional organ, such as the gut or lung, using the PhysioMimix Dual-organ plate.
By mimicking how organs interact and communicate as part of a complex system, you benefit from a deeper human-specific mechanistic understanding of disease states and drug behavior.
The CN Bio MPS system allows hepatic cultures to be grown for weeks with low signs of cytotoxicity or hepatocytes de-differentiation detectable; CN Bio has developed an efficient proprietary protocol to model NASH that shows really high homology with murine models of NASH in terms of transcriptome, inflammatory profiling and pathophysiological events crucial for disease progression
The hepatic co-cultures of hepatocytes, Kupffer and stellate cells that I have tested also behave as expected in vivo with regards to intracellular signalling pathways (such as TGFβ signalling) thus allowing the modeling of chronic liver disease pathophysiology.
I think that the PhysioMimix OOC system will become a “must-have” piece of equipment for labs focussing on liver pathophysiology and tissue-to-tissue interactions.
Michele Vacca, MD PhD
Clinician Research Associate at the Institute of Metabolic Science, University of Cambridge
View more PhysioMimix OOC reviews on SelectScience
Our models functionally mimic the organ and give a realistic expression of disease phenotypes for improved efficacy assessments
By closely mimicking in vivo function, our models better predict drug safety to support and accelerate drug development.
Single- and multi-organ models closely predict human in vivo pharmacokinetics for informed insights into the body’s effect on drugs.
Why choose PhysioMimix?
Lab benchtop ready
Portable and compact
Quick to set up
Get operational in less than an hour
Program and start a run in less than 1 minute
Use with existing equipment
Supports your 2D to 3D cell culture transition
Remove samples for analysis, experiments continue to run
Long-term automated experiments with minimal user input
Tissues and cells
Compatible with a range of pre-formed tissues and cell types for ultimate flexibility
Connect two organs via microfluidics to study cross-talk