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Harnessing the power of multimodal imaging to explore ASO distribution in cells, complex in vitro models and tissue
Filed under: ADME, Drug absorption, and Drug metabolism
Alex et al
Further advancement of antisense oligonucleotides (ASOs) in the clinic urgently requires optimization of ASO delivery, target engagement, and safety profile within human-relevant in vitro and ex-vivo systems.
This recent poster from GSK and collaborators features data from our PhysioMimix® OOC and Liver plates. The results demonstrate that the distribution of ASOs into Kupffer cells and circular or cuboidal hepatocytes cultured in 3D can be detected using imaging.
Preliminary results can be found in the poster, with the full set due to be published later this year.