Human Organ-on-a-Chip Applications | PhysioMimix®

Recreate healthy human physiology or complex human disorders in the lab

PhysioMimix Organ-on-a-chip models (or microphysiological systems) are comprised of human cells and tissues whose phenotypes and functions reliably mimic those in vivo.

By recreating human physiology in the lab, these models can be used for a myriad of contexts of use to further our understanding of disease mechanisms, uncover potential therapeutic targets, and assist with the safe and efficacious development of potential therapeutics.

Below are examples of the human-relevant purposes for which we have characterized our Organ-on-a-chip models.

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cnb1644 technet tmb v1 | Organ-on-a-chip applications

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Building better data packages: The role of MPS in modern efficacy, toxicity and ADME workflows

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Organ-on-a-chip applications utilizing a Liver-12 plate in lab

Disease modeling

Studying disease models provides insight into disease cause and progression. They help to identify potential therapeutic approaches and are used to assess drug efficacy. Our models functionally mimic the organ and give a realistic expression of the disease phenotype to ensure more clinically translatable data.

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Metabolic dysfunction-associated steatohepatitis

Hepatitis B

Pulmonary infection

Safety toxicology

Predictive safety toxicology models that closely mimic in vivo function can more accurately predict drug safety and accelerate drug development by avoiding unexpected adverse effects in human trials.

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Drug-induced liver injury

Immune-mediated liver injury

ADME

Determining the ADME properties of compounds is essential for lead optimization and candidate selection in early drug discovery. Single- and multi-organ models closely predict human in vivo pharmacokinetics for more informed decision-making.

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Drug absorption

Drug metabolism

Drug bioavailability

Oligonucleotide delivery

Customer adapted applications

Discover how researchers worldwide are leveraging PhysioMimix’s adaptable platform to advance safety toxicology, disease modeling, and ADME studies across diverse organ systems.