Filters Resource type Area of interest Posters Connecting the human intestine and liver A primary jejunum and primary hepatocyte multi-organ MPS for more predictive studies of human drug ADME and oral bioavailability Traditional immortalized intestinal cell lines and suspension hepatocytes have absent or low levels of metabolic enzyme expression, and thus fail to predict first pass human metabolism and oral bioavailability. Efforts to improve the in vitro to in vivo translation of drug efficacy and safety data has led to the emergence of more human relevant microphysiological systems (MPS) that consist of multiple, fluidically linked organs1. Articles Harnessing Microphysiological Systems to Bring Humanized Processes to ADME and Bioavailability Studies Dr. Abbas discusses the common drawbacks of using conventional methods for ADME studies that can misinform the candidate selection process and dosage figures. He talks about how emerging complementary technologies, such as organ-on-a-chip (OOC), offer human-relevant in vitro preclinical data, and how using OOC can support the determination of human bioavailability to support drug dosing regiments, reduce side effects, and potentially recover flawed therapeutic candidates. Webinars Beyond hepatotoxicity red flags Webinar Series 6 Episode 1 Standard preclinical approaches are poorly predictive, particularly for drugs eliciting human-specific toxicity or idiosynchratic DILI. In this webinar, Dr. Anthony Berger, a Field Application Scientist at CN Bio will discuss how liver-on-a-chip (LOAC) cocultures of primary hepatocytes offer a solution. Webinars Set yourself up for success with organ-on-a-chip Webinar Series 6 Episode 4 Generally, OOC models are formed from cultures of primary human cells that recreate the structure and function of human organs and tissues in vitro. Webinars Normalization of organ-on-a-chip samples Webinar Series 6 Episode 2 Mass spectrometry based ‘omics pairs well with organ-on-a-chip-based investigations, which often have limited cellular material for sampling. A common issue with chip-based platforms is well-to-well or chip-to-chip variability in the proteome and metabolome due to many factors including plate edge effects, cellular asynchronization, effluent flow, and limited cell count. Brochures & Flyers PhysioMimix Nash-in-a-box brochure NASH-in-a-box contains everything required to recreate our industry-validated in vitro human Non-Alcoholic Steatohepatitis (NASH) model in your own laboratory Blogs Taking organoids to the next level They are generally cultured from primary human cells, or stem cells, to form tissues that better represent in vivo physiology and function than 2D cell cultures, but what do next-generation organoids look like? Blogs A guide to pre-validating cells for use in Organ-on-a-chip assays We cannot emphasise enough the importance of choosing the right cells. Not all cells perform well in OOC assays and not all cell types offer the highest degree of human relevance! This in-depth blog explores the steps that we go through during our experimental planning phase to pre-validate cells for use in OOC assays. Read on to identify the easiest way to invest in your success – choose 3D validated cells from our portfolio, or, how to embark on your own pre-validation studies. Articles Recreating Life in the Lab: How Predictive Human Organ Models are Transforming the Efficiency of Drug Discovery Published on the International Biopharmaceutical Journal Volume 6 Issue 2 Learn about the New Approach Methodologies (NAMs) revolution and discover how Organ-on-a-chip technologies bridge the relevance gap between traditional preclinical assays and the human for better informed decision making across drug discovery. Podcasts Tech Blast | Organ-on-a-chip technologies Created with BioTechniques Senior Scientist, Dr Emily Richardson and Principal BioEngineer, Dr Dharaminder Singh discuss organ-on-a-chip. Including, how it differs to alternatives, what data can be generated and how to adopt the technology. Reports Summary report: Insights into new preclinical non animal models A summary industry report compiled by Citeline looking into new preclinical non-animal models. Reports Full report: Insights into new preclinical non animal models A complete industry report compiled by Citeline looking into new preclinical non-animal models.