Blogs
Immune-mediated DILI – Predicting the unpredictable!
Dr Anthony Berger discusses the limitations of the existing workflow and how organ-on-a-chip can help to predict the unpredictable, immune-mediated DILI.
Videos and animations
Introducing PhysioMimix HT…
Our latest in the PhysioMimix organ-on-a-chip (OOC) range. The groundbreaking PhysioMimix HT (higher throughput)! Designed to overcome the adoption challenges of OOC technology.
Brochures & Flyers
PhysioMimix Organ-on-a-Chip Brochure
Explore our full range of PhysioMimix organ-on-a-chip systems with our new brochure. Featuring our next-generation PhysioMimix HT (higher throughput).
Brochures & Flyers
PhysioMimix Single-organ HT system
Discover the data behind our new groundbreaking PhysioMimix HT system and Liver48 plate. Plus why it is a game-changer in the industry.
Articles
Organ-on-a-chip provides preclinical safety toxicologists with the tools to combat drug attrition
Learn how organ-on-a-chip technology is aiding toxicologists in de-risking drug-induced liver injury by providing human-specific safety data.
This article is taken from Select Science, February 2023
Articles
Organ-on-a-chip models in drug development
Learn how organ-on-a-chip (OOC) technologies succeed where organoids and spheroids fail, bridging the remaining gap between existing 2D/3D models and the human.
This article is taken from Drug Discovery World, January 2023
Videos and animations
About CN Bio…
Ever wondered what differentiates CN Bio, the people behind our brand, why we come to work every morning or our vision for the future? Here’s a snapshot of us in 3 minutes. We hope you enjoy it!
Blogs
The U.S. FDA Modernization Act 2.0. Now the animal testing mandate is removed, what can be embraced in its place?
What is the FDA Modernization Act 2.0, and what does it mean?
Scientific publications
Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay
Gallagher et al., 2022
This study shows the importance of normalization for paired MS-based multi-omics-OOC studies to accurately investigate highly toxic hazards and their effects on the human liver. Using VX, a highly toxic chemical compound, the study identifies VX-specific toxic effects on 3D liver tissues as well as specific hepatic cellular biomarkers and pathways affected by the toxic agent.
Webinars
The Human Touch
Webinar Series 5 Episode 4
In this webinar, we highlight how the liver-on-a-chip system can be used to assess the impact of HSD17B13 inhibitors on fibrosis, human metabolism and lipid droplets.
Articles
ADME Studies: Determining Promising Drug Compounds
Dr Abbas discusses factors that can affect the outcome of an ADME study, signs that a drug compound shows promise, red flags, and key parameters to determine safety and efficacy.
This article is taken from PharmTech, November 2022.
Webinars
The Dash for NASH
Webinar Series 5 Episode 3
Find out how to: rapidly adopt an organ-on-a-chip (OOC) approach to NASH research, generate clinically translatable data from an industry-proven in vitro NASH model, and how OOC can help you unlock NASH disease mechanisms, and confirm drug efficacy and safety.