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Discover the applications


Investigate the validated core application areas that our PhysioMimix® products and services support

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Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
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Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
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ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
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Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

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icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix Core

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Consumables

Multi-chip plates
3D validated cells
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Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Organ-on-a-Chip Resources

Featured

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Webinars

Building confidence for regulatory decision-making with immune competent models

Webinar Series 9 Episode 2

Discover how human liver models are building regulatory confidence in DILI risk assessment. How a continuously perfused, primary human Liver model, with immune-competent capabilities, can be leveraged to address a critical unmet need — capturing immune mediated toxicities associated with new drug modalities such as monoclonal antibodies (mAbs).

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Webinars

Building better data packages: The role of MPS in modern efficacy, toxicity and ADME workflows

Technology Network: Organoids and Microphysiological Systems Symposium 2026

Explores how MPS can be integrated into modern drug discovery workflows alongside other in vitro, in vivo and in silico tools to generate more predictive, human‑relevant data, improving translational confidence and informing decision making.

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Blogs

Integrating In Silico Tools with Organ-on-a-Chip to advance ADME studies

Knowing a drug’s bioavailability during lead optimization is crucial as it directly influences dosing strategy, therapeutic efficacy, safety margins, and formulation design.

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Posters

Maximizing data value in MPS ADME experiments using in silico modeling

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Posters

Preclinical CAR T-Cell Testing: Evaluating Efficacy and Toxicity in a 3D Perfused Melanoma Model

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Blogs

A new era of drug development: Comparing regulatory roadmaps to reduce animal testing

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Blogs

Which microphysiological system contexts of use are aligned with regulatory roadmaps?

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Scientific publications

A microphysiological model of human MASLD reveals paradoxical response to resmetirom

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Articles

Organ on a chip systems move closer to the drug development mainstream

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Articles

New Approach Methodologies (NAMs): Building more predictive drug development workflows in the changing landscape of NAMs

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Webinars

Building confidence for regulatory decision-making with immune competent models

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Webinars

Building better data packages: The role of MPS in modern efficacy, toxicity and ADME workflows

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Videos and animations

Your First Day with the PhysioMimix® Core. What’s Included? Let’s unbox!

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Videos and animations

Getting ready for Organ-on-a-chip – It’s easier than you think!

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Case studies

How LIST moved from static to fluidic organ-on-a-chip toxicology models to answer more complex questions

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

Request a meeting

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Latest news

  • Organ-on-a-chip trends shaping the next phase of human-relevant R&D from the MPS World Summit 2026 July 6, 2026
  • Which microphysiological system contexts of use are aligned with regulatory roadmaps? June 2, 2026
  • A new era of drug development: Comparing regulatory roadmaps to reduce animal testing June 2, 2026
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