Application notes
Connecting the gut and liver – coming soon
A human relevant dual-organ microphysiological system for preclinical profiling of oral bioavailability
Efforts to improve the in vitro to in vivo translation of drug efficacy and safety data has led to the emergence of more human relevant microphysiological systems (MPS). Multiple, fluidically linked MPS can be linked to form multi-organ systems that simulate human processes which can be utilized to improve ADME and bioavailability estimations. ADME and bioavailability are central in determining the safety and toxicology profiles of compounds and are therefore crucial preclinical drug development measurements.
Posters
Connecting the human intestine and liver
A primary jejunum and primary hepatocyte multi-organ MPS for more predictive studies of human drug ADME and oral bioavailability
Traditional immortalized intestinal cell lines and suspension hepatocytes have absent or low levels of metabolic enzyme expression, and thus fail to predict first pass human metabolism and oral bioavailability.
Efforts to improve the in vitro to in vivo translation of drug efficacy and safety data has led to the emergence of more human relevant microphysiological systems (MPS) that consist of multiple, fluidically linked organs1.
Articles
Harnessing Microphysiological Systems to Bring Humanized Processes to ADME and Bioavailability Studies
Dr. Abbas discusses the common drawbacks of using conventional methods for ADME studies that can misinform the candidate selection process and dosage figures. He talks about how emerging complementary technologies, such as organ-on-a-chip (OOC), offer human-relevant in vitro preclinical data, and how using OOC can support the determination of human bioavailability to support drug dosing regiments, reduce side effects, and potentially recover flawed therapeutic candidates.
Webinars
Beyond hepatotoxicity red flags
Webinar Series 6 Episode 1
Standard preclinical approaches are poorly predictive, particularly for drugs eliciting human-specific toxicity or idiosynchratic DILI. In this webinar, Dr. Anthony Berger, a Field Application Scientist at CN Bio will discuss how liver-on-a-chip (LOAC) cocultures of primary hepatocytes offer a solution.
Webinars
Set yourself up for success with organ-on-a-chip
Webinar Series 6 Episode 4
Generally, OOC models are formed from cultures of primary human cells that recreate the structure and function of human organs and tissues in vitro.
Webinars
Normalization of organ-on-a-chip samples
Webinar Series 6 Episode 2
Mass spectrometry based ‘omics pairs well with organ-on-a-chip-based investigations, which often have limited cellular material for sampling. A common issue with chip-based platforms is well-to-well or chip-to-chip variability in the proteome and metabolome due to many factors including plate edge effects, cellular asynchronization, effluent flow, and limited cell count.
Brochures & Flyers
PhysioMimix Nash-in-a-box brochure
NASH-in-a-box contains everything required to recreate our industry-validated in vitro human Non-Alcoholic Steatohepatitis (NASH) model in your own laboratory
Blogs
Taking organoids to the next level
They are generally cultured from primary human cells, or stem cells, to form tissues that better represent in vivo physiology and function than 2D cell cultures, but what do next-generation organoids look like?
Blogs
A guide to pre-validating cells for use in Organ-on-a-chip assays
We cannot emphasise enough the importance of choosing the right cells. Not all cells perform well in OOC assays and not all cell types offer the highest degree of human relevance! This in-depth blog explores the steps that we go through during our experimental planning phase to pre-validate cells for use in OOC assays. Read on to identify the easiest way to invest in your success – choose 3D validated cells from our portfolio, or, how to embark on your own pre-validation studies.
Articles
Recreating Life in the Lab: How Predictive Human Organ Models are Transforming the Efficiency of Drug Discovery
Published on the International Biopharmaceutical Journal Volume 6 Issue 2
Learn about the New Approach Methodologies (NAMs) revolution and discover how Organ-on-a-chip technologies bridge the relevance gap between traditional preclinical assays and the human for better informed decision making across drug discovery.
Podcasts
Tech Blast | Organ-on-a-chip technologies
Created with BioTechniques
Senior Scientist, Dr Emily Richardson and Principal BioEngineer, Dr Dharaminder Singh discuss organ-on-a-chip. Including, how it differs to alternatives, what data can be generated and how to adopt the technology.
Reports
Summary report: Insights into new preclinical non animal models
A summary industry report compiled by Citeline looking into new preclinical non-animal models.