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COVID-19

How do you investigate the mechanisms of COVID-19 disease?


There is an increasing emergence of previously unknown pathogens and antimicrobial resistance. COVID-19 has been an exemplar of the requirement for more rapid understanding and therapeutic design against novel pathogens.

The lung is the only internal organ directly subject to the environment and is therefore particularly vulnerable to pathogens. This, together with the increasing emergence of novel pathogens and antimicrobial resistance, has resulted in lower respiratory infections being a leading cause of death worldwide.

However, the likelihood of new pulmonary therapeutics reaching the market is only 3% compared to 6-14% for other disease therapeutics. This extremely high attrition rate can be partly attributed to the lack of reliable, predictive preclinical models that capture the intricacies of the human lung.

Our solution

Our two perfused multi-cell Lung-on-a-chip (alveolar and bronchial airway) models map the distinct physiology of the human lung, making it possible to study the mechanism of SARS-CoV-2 infection for drug screening, drug response, host-pathogen interactions, and immune response.

Our models show improved differentiation of alveolar and bronchial cells into physiologically relevant phenotypes that provide superior tissue formation and differentiation into key cell types found in the human lung.

PhysioMimix® COVID-19 Assays offer the possibility to study infection of the upper and lower airway. The co-cultures of epithelial and endothelial cells with multiple immune cell populations, including recirculating immune cells, accurately recapitulate the viral life cycle and host response.

COVID cells
Innovate UK Logo

This application was developed using funding from InnovateUK

Studying COVID-19

Limitations with current techniques

  • The lung biology and immunology of animal models vary from humans
  • Inability to track specific immune responses to pathogens
  • Simple cell models (e.g. VeroE6) only model virus entry and replication
  • Animals are needed to look at the systemic effects of infection

Advancements with PhysioMimix OOC

  • Our lung models infected by SARS-CoV-2  produce physiologically-relevant inflammatory responses for therapeutic testing
  • Complex co-culture provides phenotypes that reflect human physiology and immunology
  • Ability to add multiple human immune cells (tissue-specific and circulating)
  • Understand the basic virology, biology, and immunology of SARS-CoV-2 infection in humans
  • Lung models can be connected to other organ systems to study multi-organ effects

Human-relevant immune responses mapped over time


The inflammatory responses of alveolar Lung-on-a-chip models following infection by pseudotyped lentivirus expressing SARS-CoV-2 Spike protein demonstrate physiological relevance.

Immune response cells
Immune response line graphs

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Rapidly determine the efficacy of novel therapeutics


Assess the ability of drugs to inhibit the infection of cells or to decrease inflammatory responses.

cells showing efficacy of novel therapeutics
decrease in inflammatory responses graph
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Add PhysioMimix OOC into your lab


Harness the power of PhysioMimix OOC in your own lab with the purchase of a single- or multi-organ microphysiological system.

With a growing community of users and support from our experts, there has never been a better time to transition into 3D cell culture.

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Featured resources

Posters

Alveolar and bronchial human microphysiological EDIT |

Alveolar and bronchial human microphysiological systems for use in respiratory infection research and therapeutics evaluation

Webinars

web s5e1 |

A Breath of Fresh Air

Blogs

blog lung in crisis |

The lung in crisis

View all COVID-19 related resources

Speak to our experts

Speak directly with one of our OOC experts to see how our products and services can support your studies

Request a meeting

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Latest news

  • Immune-mediated DILI – Predicting the unpredictable! March 16, 2023
  • CN Bio appoints Deepak Singh as Vice President of Sales and Marketing March 14, 2023
  • CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System   February 27, 2023

Upcoming events

MPS World Summit 2023 June 26-30, 2023

SLAS Europe 2023 May 22-26, 2023

SOT 2023 March 19-23, 2023

WORD 2023 March 22, 2022