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Introducing the new PhysioMimix Single-Organ Higher Throughput System

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      PhysioMimix® products enable you to recreate complex human biology and accurately predict human drug responses

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      ADME

      • Drug absorption
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      Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

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      • CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System  

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Model ADME in vitro

ADME studies assess the body’s effect on a drug from initial absorption, distribution to organs and tissues, metabolism and final excretion

ADME data is collected during drug discovery and preclinical phases to optimize drug properties, support candidate selection, and subsequently inform the design of the clinical phase.

Current industry methods

Simple in vitro ADME models often lack physiological relevance. Animal models circumvent this but a host of interspecies differences, for example in cytochrome p450, limit their predictability. Use of in silico modeling to improve the translatability of preclinical ADME data remains constrained by the quality of input data.

Advancements with PhysioMimix®

PhysioMimix models are highly metabolically competent, with expression of a full range of cytochrome p450s and transporters.
Multi-organ experiments recreate the process of drug absorption and first-pass metabolism to derive bioavailability, offering enhanced predictivity versus animal models.

LC12 plate

Drug absorption


Absorption plays a critical role in determining the exposure of organs and tissues to a drug. A deeper understanding of the absorption process can help to achieve better bioavailability and refine dose. Recreating human representative absorption models is challenging, making it difficult to accurately measure this important parameter.

Our co-culture gut and lung absorption assays provide in vivo-like biological barrier properties to study compound absorption rates and more closely predict human outcomes.

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LC12 plate

Drug metabolism


Drug metabolism in the body is a complex process where drugs are structurally modified forming metabolites. Studying drug metabolism and pharmacokinetics (DMPK) is vital to identify lead compounds with optimal PK/PD properties, minimize any potential safety issues, and ensure efficient translation to the clinic.

Our liver, lung, and gut in vitro models can be used separately or in combination to study drug metabolism. These stable, human models accurately mimic the complexity of the physiological environment and offer a major advance for studying DMPK.

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LC12 plate

Drug bioavailability


Understanding the bioavailability of orally administered drugs is an essential part of the discovery process. Animals are notoriously poor predictors of human bioavailability and this leads to clinical failures.

Our multi-organ oral bioavailability assay with connected gut and liver models can provide accurate predictions of human bioavailability early in drug development, improving the chance of success in clinical trials.

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Jump to area of interest

Drug absorption
Drug metabolism
Drug bioavailability

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Speak directly with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • Immune-mediated DILI – Predicting the unpredictable! March 16, 2023
  • CN Bio appoints Deepak Singh as Vice President of Sales and Marketing March 14, 2023
  • CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System   February 27, 2023

Upcoming events

MPS World Summit 2023 June 26-30, 2023

SLAS Europe 2023 May 22-26, 2023

SOT 2023 March 19-23, 2023

WORD 2023 March 22, 2022