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PhysioMimix™ NASH-in-a-box

Fast-track your route to successful NASH therapeutic development with our 3D NASH model


NASH-in-a-box contains everything required to recreate our industry-validated human in vitro Non-Alcoholic Steatohepatitis (NASH) model in your own laboratory. It is designed for use with our PhysioMimix OOC range of single- and multi-organ microphysiological systems.

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Cells under microscope

NASH-in-a-box supports:

  • The rapid adoption of an organ-on-a-chip approach by scientists, irrespective of their experience
  • Instant access to validated protocols developed and refined through years of industry collaboration
  • Generation of high-content clinically translatable data to unlock disease mechanisms and confirm drug efficacy and safety
MPS-LC12 plate

Features of the NASH-in-a-box kit

Use NASH-in-a-box to address the limitations of traditional approaches and avoid unexpected results in the clinic.

  • PhysioMimix OOC compatible
  • Software-guided protocols
  • 3D validated primary human hepatocytes, stellate, and Kupffer cells
  • Proprietary NASH media and supplements
  • Assay kits to quality control cultured 3D liver microtissues

NASH-in-a-box animation

This short animation describes how our NASH-in-a-box kit enhances your chance of successfully developing NASH therapeutics by recreating our industry-proven NASH model in your laboratory.


How does NASH-in-a-box compare?

There are a wide range of preclinical research and development tools available. How does NASH-in-a-box compare to more traditional approaches?

In vitro 2D cell cultureIn vitro 3D spheroidIn vivo animal modelsOrgan-on-a-chip
Human relevance
Data contentLOWMEDIUMHIGHHIGH
Longevity< 7 days< 7 days> 4 weeks2-4 weeks
Model complexity
Throughput
Ease of adoption
Cost$$$$$$$
Time to result
NASH phenotype

Related applications

Non-alcoholic steatohepatitis

NASH-in-a-box logo
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Learn more about PhysioMimix OOC

Featured resources

Infographic

My project 1 24 |

Pros and cons of preclinical models of Non-Alcoholic Steatohepatitis

Podcasts

My project copy 1 1 |

Organ-on-a-Chip Models of Fatty Liver Disease

Webinars

cnb653 dash for nash resource |

The Dash for NASH: How To Succeed in NASH Therapeutic Development

Speak to our experts

Speak directly with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system January 17, 2023
  • The U.S. FDA Modernization Act 2.0. Now the animal testing mandate is removed, learn what can be embraced in its place. January 9, 2023
  • CN Bio appoints Dr Paul Brooks as Chief Executive Officer December 19, 2022

Upcoming events

MPS World Summit 2023 June 26-30, 2023

SLAS Europe 2023 May 22-26, 2023

SLAS2023 February 25 - March 1, 2023