WEBINAR: Normalization of organ-on-a-chip samples for mass spectrometry based proteomics and metabolomics via dansylation-based assay – 28 June 2023

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PhysioMimix® NASH-in-a-box

Fast-track your route to successful NASH therapeutic development with our in vitro 3D NASH model


NASH-in-a-box contains everything required to recreate our industry-validated human in vitro Non-Alcoholic Steatohepatitis (NASH) model in your own laboratory. It is designed for use with our PhysioMimix OOC range of single- and multi-organ microphysiological systems.

Cells under microscope

NASH-in-a-box supports:

  • The rapid adoption of an organ-on-a-chip approach by scientists, irrespective of their experience
  • Instant access to validated protocols developed and refined through years of industry collaboration
  • Generation of high-content clinically translatable data to unlock disease mechanisms and confirm drug efficacy and safety
MPS-LC12 plate

Features of our 3D NASH model

Use NASH-in-a-box to address the limitations of traditional approaches and avoid unexpected results in the clinic.

  • PhysioMimix OOC compatible
  • Software-guided protocols
  • 3D validated primary human hepatocytes, stellate, and Kupffer cells
  • Proprietary NASH media and supplements
  • Assay kits to quality control cultured 3D liver microtissues

NASH-in-a-box animation

This short animation describes how our NASH-in-a-box kit enhances your chance of successfully developing NASH therapeutics by recreating our industry-proven 3D NASH model in your laboratory.


How does our 3D NASH model compare?

There are a wide range of preclinical research and development tools available. How does NASH-in-a-box compare to more traditional approaches?

In vitro 2D cell cultureIn vitro 3D spheroidIn vivo animal modelsOrgan-on-a-chip
Human relevance
Data contentLOWMEDIUMHIGHHIGH
Longevity< 7 days< 7 days> 4 weeks2-4 weeks
Model complexity
Throughput
Ease of adoption
Cost$$$$$$$
Time to result
NASH phenotype

Related applications

Non-alcoholic steatohepatitis

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Featured resources

Infographic

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Pros and cons of preclinical models of Non-Alcoholic Steatohepatitis

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Organ-on-a-Chip Models of Fatty Liver Disease

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The Dash for NASH

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Speak directly with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • Immune-mediated DILI – Predicting the unpredictable! March 16, 2023
  • CN Bio appoints Deepak Singh as Vice President of Sales and Marketing March 14, 2023
  • CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System   February 27, 2023

Upcoming events

ISSX DMDG 2023 June 11-14, 2023

MPS World Summit Berlin 2023 June 26-30, 2023