Improve in vitro to in vivo data translation for drug safety and efficacy with our fluidically-linked dual-organ MPS (microphysiological system); combining two well-characterized human Gut/Liver MPS – the RepliGut^® Jejunum and PhysioMimix^® Liver MPS, in an interconnected model suitable for enhanced bioavailability profiling.

The liver and intestinal cells are first validated separately, then as a functional, fluidically-coupled co-culture system. We then ensure all cells are metabolically suitable for ADME studies before demonstrating how the pre-clinical assay can be used to provide a deeper mechanistic understanding of a drug’s oral bioavailability in vitro, allowing drug developers to only progress the most promising therapeutic candidates through the pipeline.