Investigate organ-to-organ crosstalk with our PhysioMimix Dual-organ plate
Each PhysioMimix Dual-organ plate enables six multi-organ systems to be created in vitro. Each system is comprised of two individually cultured organs that are able to communicate via inter-organ fluidic flow.
Six independently grown biological barrier models (e.g., Lung-, or Gut-on-a-chip) are generated by culturing primary human cells on the apical and basolateral sides of a Transwell® insert. Six liver-on-a-chip models, consisting of primary human liver cells cocultured in 3D using an engineered scaffold, are grown in the liver compartment. An interconnected pneumatic pump facilitates communication between the two models.
Dual-organ models accurately recapitulate complex human systems, providing a human-relevant alternative to the use of animals.
Our plates are compatible with:
- primary cells
- induced-pluripotent stem cells
- immortalized cell lines
- circulating immune cells
- precision-cut tissue slices
They are designed for use with the PhysioMimix Multi-organ System and can be used for a variety of applications.