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Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix OOC

physiomimix-single-and-multi-organ-on-a-chip-systems
Learn more

Consumables

Multi-chip plates
3D validated cells
NASH-in-a-box
Bioavailability assay kit: Human 18
DILI assay kit: Human 24
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Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Discover the applications


Investigate the application areas that our PhysioMimix® products and services support

Learn more

Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
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Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
Learn more

ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
Learn more

Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

Learn more
icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

PhysioMimix® Barrier plate

Generate more physiologically relevant barrier models in vitro with the PhysioMimix Barrier plate


PhysioMimix Barrier plates enable primary human cells to be cocultured on the apical and basolateral sides of a Transwell® insert to recreate biological barrier models.

Epithelial and endothelial cells may be cultured at an air-liquid interface (ALI) or in the presence of media. Circular flow perfusion on the basolateral side recreates a physiologically relevant microenvironment within each of the plate’s 12 chips.

This provides continuous access to oxygen and nutrients for long-term culture and facilitates the creation of 3D-like biological barrier tissue with more in vivo representative morphology and integrity than static cultures.

These plates accommodate standard 0.33 cm2 Transwell inserts and are
compatible with:

  • primary cells
  • induced-pluripotent stem cells
  • immortalized cell lines
  • circulating immune cells
  • organoids
  • commercial inserts (such as MucilAir® or EpiSkin®).

Barrier plates are designed for use with PhysioMimix OOC systems and can be used for a variety of applications.


PhysioMimix Barrier model applications

Pulmonary infection

Immune-mediated toxicity

Drug absorption


Related consumables

Dual-organ plate


Learn more about PhysioMimix OOC
See other consumables
PhysioMimix® Barrier plate
PhysioMimix® Barrier plate well close up

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

Request a meeting

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