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Discover the applications


Investigate the validated core application areas that our PhysioMimix® products and services support

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Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
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Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
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ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
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Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

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icon-dili-tox-150x150.png Drug-induced liver injury
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Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix Core

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Consumables

Multi-chip plates
3D validated cells
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Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Organ-on-a-Chip Resources

Featured

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Webinars

Building confidence for regulatory decision-making with immune competent models

Webinar Series 9 Episode 2

Discover how human liver models are building regulatory confidence in DILI risk assessment. How a continuously perfused, primary human Liver model, with immune-competent capabilities, can be leveraged to address a critical unmet need — capturing immune mediated toxicities associated with new drug modalities such as monoclonal antibodies (mAbs).

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Webinars

Building better data packages: The role of MPS in modern efficacy, toxicity and ADME workflows

Technology Network: Organoids and Microphysiological Systems Symposium 2026

Explores how MPS can be integrated into modern drug discovery workflows alongside other in vitro, in vivo and in silico tools to generate more predictive, human‑relevant data, improving translational confidence and informing decision making.

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Blogs

Integrating In Silico Tools with Organ-on-a-Chip to advance ADME studies

Knowing a drug’s bioavailability during lead optimization is crucial as it directly influences dosing strategy, therapeutic efficacy, safety margins, and formulation design.

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Application notes

Enhance IVIVE with cross-species Liver MPS DILI assays

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Application notes

Accelerating DILI Prediction: A High-Throughput Liver-on-a-Chip Solution

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Application notes

A liver microphysiological system to study the delivery and efficacy of oligonucleotide-based therapeutics

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Application notes

Evaluating a human DILI assay’s ability to unlock complex mechanisms of toxicity

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Application notes

Developing a translational biomarker panel for use in pre-clinical advanced in vitro studies of Non-alcoholic steatohepatitis

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Application notes

Connecting the gut and liver

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Application notes

Alveolar and Bronchial Microphysiological Systems for respiratory infection research and therapeutics evaluation

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Application notes

Human liver microphysiological system for predicting the drug-induced liver toxicity of differing drug modalities

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Application notes

Microphysiological system for studying fatty liver disease and its impact on drug-induced liver injury

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Application notes

Improved prediction of oral bioavailability using a gut-liver microphysiological system

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Application notes

Drug metabolism in a gut-liver microphysiological system

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Application notes

Predicting human drug permeability with a gut microphysiological system

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • Organ-on-a-chip trends shaping the next phase of human-relevant R&D from the MPS World Summit 2026 July 6, 2026
  • Which microphysiological system contexts of use are aligned with regulatory roadmaps? June 2, 2026
  • A new era of drug development: Comparing regulatory roadmaps to reduce animal testing June 2, 2026
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