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Drug metabolism in a gut-liver microphysiological system
Filed under: ADME, Drug absorption, and Drug metabolism
Abbas, Kostrzewski & Hughes
Microphysiological systems (MPS) enable the generation of in vitro 3D organ models whose purpose is to accurately represent their human body counterparts.
To date, these systems mainly use single-organ models in isolation, however, more complex MPS models that incorporate multiple tissues related to ADME are required to further improve the prediction of in vivo PK/PD.
Using a multi-organ gut and liver microphysiological system (MPS), this study investigates the permeability of an orally administered drug through an intestinal barrier and its subsequent hepatic metabolism to establish if more accurate predictions of in vivo hepatic clearance rates are achieved using interconnected organs that operate in synergy, versus organs studied in isolation.