Bray et al

In recent years, efforts have been put into improving those in vitro models, in particular with the use of microphysiological system (MPS), also known as Organ-on-a-Chip (OOC). MPS aim to better represent the physiology, structure and functions of human tissues and organs. In this Application Note, we show how we developed and characterised a gut MPS closely aligned to the human small intestine, using the PhysioMimix™ Single-Organ system, and demonstrated its utility to predict drug permeability.