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Predicting human drug permeability with a gut microphysiological system
Filed under: ADME and Drug absorption
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About this application note:
Preclinical drug absorption studies are a key step when developing when therapeutics as they determine how much of orally-administered drug reaches the systemic circulation. Here, we show how we developed and characterized a gut MPS closely aligned to the human small intestine, using the PhysioMimix® Single-Organ system, and demonstrated its utility to predict drug permeability.
In recent years, efforts have been put into improving those in vitro models, in particular with the use of microphysiological system (MPS), also known as Organ-on-a-Chip (OOC). MPS aim to better represent the physiology, structure and functions of human tissues and organs. In this Application Note, we show how we developed and characterised a gut MPS closely aligned to the human small intestine, using the PhysioMimix® Single-Organ system, and demonstrated its utility to predict drug permeability.
Alysha Bray, Lucy-May Young, Dr Yassen Abbass & Dr Tomasz Kostrzewski