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Predicting human drug permeability with a gut microphysiological system
Filed under: ADME and Drug absorption

Bray et al
In recent years, efforts have been put into improving those in vitro models, in particular with the use of microphysiological system (MPS), also known as Organ-on-a-Chip (OOC). MPS aim to better represent the physiology, structure and functions of human tissues and organs. In this Application Note, we show how we developed and characterised a gut MPS closely aligned to the human small intestine, using the PhysioMimix™ Single-Organ system, and demonstrated its utility to predict drug permeability.