3D Cell Culture

3D cell culture is a key tool in the study of human cells and organs. The biomimetic structures formed better replicate the microenvironments, cell-cell interactions and biological processes that occur in vivo, bridging the gap between traditional cell culture and human studies.

Other benefits include enabling more co-culture options, creating polarised tissues and allowing for longer term growth. In drug development this allows scientists to design assays which mimic how organs absorb, distribute, metabolize, and eliminate (known as ADME) drugs and other chemicals in vitro.

3D Cell Culture Using PhysioMimix™ OOC

Our microphysiological systems (MPS) allow researchers to set up human 3D cell culture assays and generate results quickly.

Cells cultured on 3D scaffolds embedded in the wells on PhysioMimixplates:

  • Are continually perfused by cell culture medium during experiments
  • Create optimal culture conditions for functional human organ microtissues
  • Allow scientists to predict the effects of compounds on human organs

In 2018, the PhysioMimix™ 3D cell culture system won the Innovation Award at the UK’s largest laboratory event, Lab Innovations, selected from hundreds of innovative laboratory products

Setting Up 3D Cell Culture Experiments

PhysioMimix™ OOC  can be used to run 3D cell culture assays for a range of cell formats:

  • Fresh or cryopreserved cells
  • Pre-formed tissues or organoids
  • Organ and tissue slices
  • Customised or commercial inserts

Human organ
mimics

Powerful new
data

Translatable
results

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