Articles

Addressing the challenges of developing new modality drugs
Discover how new modality drugs are revolutionizing medicine by targeting complex diseases with cutting-edge therapies. Learn about the challenges, innovative solutions, and the role of AI and Organ-on-a-chip (OOC) technology in new modality drug development. Expert insights.
Articles

Next Generation Drug Discovery: Bridging the Gap with Organ-on-a-Chip Technology
In today’s drug development landscape, there is a critical need for more human-relevant preclinical testing models. Traditional in vitro assays and in vivo animal models often fall short in predicting human outcomes, especially as advanced drug modalities with human-specific actions become more prevalent. Organ-on-a-Chip (OOC) technology, a groundbreaking solution designed to replicate human physiology and function in vitro, offers a promising path forward.
Blogs

How Organ-on-a-Chip Addresses R&D Challenges
Our blog explores recent nomenclature changes and advances in the field of metabolic dysfunction-associated steatohepatitis (MASH), the R&D challenges that remain and how organ-on-a-chip is transforming liver disease research.
Application notes

Developing a translational biomarker panel for use in pre-clinical advanced in vitro studies of Non-alcoholic steatohepatitis
Download the Application Note to discover a primary human Non-alcoholic steatohepatitis (NASH) microphysiological system (MPS) that more closely models the human liver and NASH disease.
Explore the model’s ability to recapitulate an advanced NASH phenotype (characterized by fibrosis), quantify the expression of biomarkers and assess the efficacy of four anti-NASH compounds that entered human clinical trials.
Brochures & Flyers

PhysioMimix Nash-in-a-box brochure
NASH-in-a-box contains everything required to recreate our industry-validated in vitro human Non-Alcoholic Steatohepatitis (NASH) model in your own laboratory
Brochures & Flyers

Organ-on-a-chip Contract Research Services Brochure
Discover our full range of Organ-on-a-chip contract research services including ADME, NASH, DILI and Oncology as well as all the relevant endpoints.
Posters

Modelling the intestine-liver axis: The role of FXR agonists in a multi-organ microphysiological system model of non-alcoholic fatty liver disease
Here, we demonstrate the potential of a liver and a gut/liver microphysiological systems (MPS) to recapitulate NAFLD and NASH phenotypes in vitro and explore the molecular mechanisms underlying the development of NAFLD/NASH as well as assess the efficacy of novel therapeutic strategies.
Webinars

The Human Touch
Webinar Series 5 Episode 4
In this webinar, we highlight how the liver-on-a-chip system can be used to assess the impact of HSD17B13 inhibitors on fibrosis, human metabolism and lipid droplets.
Webinars

The Dash for NASH
Webinar Series 5 Episode 3
Find out how to: rapidly adopt an organ-on-a-chip (OOC) approach to NASH research, generate clinically translatable data from an industry-proven in vitro NASH model, and how OOC can help you unlock NASH disease mechanisms, and confirm drug efficacy and safety.
Application notes

Microphysiological system for studying fatty liver disease and its impact on drug-induced liver injury
Kostrzewski et al
As a result of the increased prevalence of diabetes, obesity, and metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease in developed countries. Using better in vitro models to fast-track therapeutic development but also accurately assess DILI risk in NASH patients ahead of the clinic is critical. Here, we show the potential of an in vitro 3D NASH model to accurately identify any DILI-associated risks.
Infographic

Pros and cons of preclinical models of Non-Alcoholic Steatohepatitis
This infographic was made by Biotechniques to help educate people on our NASH-in-a-box kit and how it sets a new standard in the search for an approved NASH therapeutic.
Videos and animations

In Focus: Modeling NASH disease – organ-on-a-chip technologies
This short animation describes how our NASH-in-a-box kit enhances your chance of successfully developing NASH therapeutics by recreating our industry-proven NASH model in your laboratory. Created by Biotechniques.