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Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix OOC

physiomimix-single-and-multi-organ-on-a-chip-systems
Learn more

Consumables

Multi-chip plates
3D validated cells
NASH-in-a-box
Bioavailability assay kit: Human 18
DILI assay kit: Human 24
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Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Discover the applications


Investigate the application areas that our PhysioMimix® products and services support

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Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
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Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
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ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
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Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

Learn more
icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

Organ-on-a-Chip Resources

Resource type

Area of interest

Articles

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Addressing the challenges of developing new modality drugs

Discover how new modality drugs are revolutionizing medicine by targeting complex diseases with cutting-edge therapies. Learn about the challenges, innovative solutions, and the role of AI and Organ-on-a-chip (OOC) technology in new modality drug development. Expert insights.

Articles

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Next Generation Drug Discovery: Bridging the Gap with Organ-on-a-Chip Technology

In today’s drug development landscape, there is a critical need for more human-relevant preclinical testing models. Traditional in vitro assays and in vivo animal models often fall short in predicting human outcomes, especially as advanced drug modalities with human-specific actions become more prevalent. Organ-on-a-Chip (OOC) technology, a groundbreaking solution designed to replicate human physiology and function in vitro, offers a promising path forward.

Blogs

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How Organ-on-a-Chip Addresses R&D Challenges

Our blog explores recent nomenclature changes and advances in the field of metabolic dysfunction-associated steatohepatitis (MASH), the R&D challenges that remain and how organ-on-a-chip is transforming liver disease research.

Application notes

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Developing a translational biomarker panel for use in pre-clinical advanced in vitro studies of Non-alcoholic steatohepatitis

Download the Application Note to discover a primary human Non-alcoholic steatohepatitis (NASH) microphysiological system (MPS) that more closely models the human liver and NASH disease.

Explore the model’s ability to recapitulate an advanced NASH phenotype (characterized by fibrosis), quantify the expression of biomarkers and assess the efficacy of four anti-NASH compounds that entered human clinical trials.

Brochures & Flyers

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PhysioMimix Nash-in-a-box brochure

NASH-in-a-box contains everything required to recreate our industry-validated in vitro human Non-Alcoholic Steatohepatitis (NASH) model in your own laboratory

Brochures & Flyers

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Organ-on-a-chip Contract Research Services Brochure

Discover our full range of Organ-on-a-chip contract research services including ADME, NASH, DILI and Oncology as well as all the relevant endpoints.

Posters

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Modelling the intestine-liver axis: The role of FXR agonists in a multi-organ microphysiological system model of non-alcoholic fatty liver disease

Here, we demonstrate the potential of a liver and a gut/liver microphysiological systems (MPS) to recapitulate NAFLD and NASH phenotypes in vitro and explore the molecular mechanisms underlying the development of NAFLD/NASH as well as assess the efficacy of novel therapeutic strategies.

Webinars

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The Human Touch

Webinar Series 5 Episode 4

In this webinar, we highlight how the liver-on-a-chip system can be used to assess the impact of HSD17B13 inhibitors on fibrosis, human metabolism and lipid droplets.

Webinars

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The Dash for NASH

Webinar Series 5 Episode 3

Find out how to: rapidly adopt an organ-on-a-chip (OOC) approach to NASH research, generate clinically translatable data from an industry-proven in vitro NASH model, and how OOC can help you unlock NASH disease mechanisms, and confirm drug efficacy and safety.

Application notes

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Microphysiological system for studying fatty liver disease and its impact on drug-induced liver injury

Kostrzewski et al

As a result of the increased prevalence of diabetes, obesity, and metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease in developed countries. Using better in vitro models to fast-track therapeutic development but also accurately assess DILI risk in NASH patients ahead of the clinic is critical. Here, we show the potential of an in vitro 3D NASH model to accurately identify any DILI-associated risks.

Infographic

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Pros and cons of preclinical models of Non-Alcoholic Steatohepatitis

This infographic was made by Biotechniques to help educate people on our NASH-in-a-box kit and how it sets a new standard in the search for an approved NASH therapeutic.

Videos and animations

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In Focus: Modeling NASH disease – organ-on-a-chip technologies

This short animation describes how our NASH-in-a-box kit enhances your chance of successfully developing NASH therapeutics by recreating our industry-proven NASH model in your laboratory. Created by Biotechniques.

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

Request a meeting

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Latest news

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