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PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

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icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

The Human Touch

November 28, 2022

Resource > Webinars >

The Human Touch


Primary Human Microphysiological Systems for Testing HSD17B13 Inhibitors

Filed under: Disease modeling and MASLD/MASH

cnb659 human touch webinar v1 |

Video content if present

Watch this webinar to find out how:

 

  • to rapidly adopt an organ-on-a-chip approach to NASH research
  • to generate clinically translatable data from an industry-proven in vitro NASH model
  • organ-on-a-chip can help you unlock NASH disease mechanisms and confirm drug efficacy and safety

 

Non-alcoholic steatohepatitis (NASH) is a highly prevalent disease, currently unmet therapeutically. NASH is characterized by fat accumulation in the liver leading to chronic fibrosis and inflammation, which can progress to cirrhosis and hepatocellular carcinoma.

Its progression is associated with fatty diets, dysregulation of metabolism and genetic predisposition. Several genes linked to NASH development are associated with lipid droplets, including HSD17B13 which encodes a metabolic enzyme in the lipid droplet membrane.

CN Bio’s Liver-on-a-chip, cultured under a high fat stress, provides a human-relevant NASH model for characterizing drugs targeting metabolism. In this webinar, we highlight how the liver-on-a-chip system can be used to assess the impact of HSD17B13 inhibitors on fibrosis, human metabolism and lipid droplets.


Speaker Information:

Dr-Gareth-Guenigault Dr Gareth Guenigault

Lead Scientist CRO Services
CN Bio

 

Dr-Heather-Kay-Webb-Hsu Dr Heather Kay Webb Hsu

Chief Scientific Officer
Inipharm

Video content if present

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