Posters
Why two organs are better than one
Abbas, Kostrzewski & Hughes
This poster demonstrates how a gut-liver MPS can improve oral bioavailability predictions by mimicking human oral and IV regimens. Thus improving the in vitro to in vivo translation of drug efficacy and safety.
Articles
Predicting Drug Bioavailability with the Modern-Day Toolkit
Animal models continue to be used in bioavailability research but limitations are serious and difficult to overcome. Find out how OOC can help solve your PK/PD and bioavailability issues.
This article is taken from International Biopharmaceutical Industry Winter 2021, pages 14-17.
Application notes
Improved prediction of oral bioavailability using a gut-liver microphysiological system
Abbas, Kostrzewski & Hughes
Central to the development of new drugs is an understanding of their pharmacokinetic properties, in particular their bioavailability. Here, we demonstrate the potential of a true 2-organ gut-liver MPS to better predict human bioavailability and improve in vitro to in vivo correlation.
Webinars
From Dose to Circulation: Determination of Drug Oral Bioavailability Using a Gut-Liver Microphysiological System
Webinar Series 4 Episode 4
In this webinar, Dr. Yassen Abbas discusses how CNBio’s gut-liver MPS can be used for in vitro determination of oral bioavailability. This application has been validated with drugs with known human bioavailability and with a mathematical model developed to enable prediction of oral bioavailability in silico.
Posters
Microphysiological systems of the human liver, gut and linked liver-gut, to assess human drug absorption, metabolism and bioavailbility
Kostrzewski et al
This poster demonstrates the potential of human MPS models for liver, gut, and multi-organ (connecting gut with liver) for the investigation of human PK parameters, drug absorption and metabolism, and bioavailability.
Webinars
Towards a Body-on-a-Chip: The Value of Multi-Organ MPS for Human-Relevant Drug Assessment
Webinar Series 3 Episode 1:
In this webinar, Dr Tomasz Kostrzewski, VP – Science & Technology explores how single-and multi-organ MPS can be incorporated into your drug discovery and development workflows to increase in vitro to in vivo translation of preclinical assays.
Posters
in silico modeling as a promising tool for investigation of mycophenolate mofetil pharmocokinetics">
Gut-liver organ-on-a-chip combined with in silico modeling as a promising tool for investigation of mycophenolate mofetil pharmocokinetics
Milano et al
This poster demonstrates the potential of a true 2-organ gut-liver MPS for ADME applications and is more relevant in vitro to in vivo translation of drug efficacy and toxicity.