Filters Resource type Area of interest Posters Connecting the human intestine and liver A primary jejunum and primary hepatocyte multi-organ MPS for more predictive studies of human drug ADME and oral bioavailability Traditional immortalized intestinal cell lines and suspension hepatocytes have absent or low levels of metabolic enzyme expression, and thus fail to predict first pass human metabolism and oral bioavailability. Efforts to improve the in vitro to in vivo translation of drug efficacy and safety data has led to the emergence of more human relevant microphysiological systems (MPS) that consist of multiple, fluidically linked organs1. Articles Harnessing Microphysiological Systems to Bring Humanized Processes to ADME and Bioavailability Studies Dr. Abbas discusses the common drawbacks of using conventional methods for ADME studies that can misinform the candidate selection process and dosage figures. He talks about how emerging complementary technologies, such as organ-on-a-chip (OOC), offer human-relevant in vitro preclinical data, and how using OOC can support the determination of human bioavailability to support drug dosing regiments, reduce side effects, and potentially recover flawed therapeutic candidates. Brochures & Flyers Organ-on-a-chip Contract Research Services Brochure Discover our full range of Organ-on-a-chip contract research services including ADME, NASH, DILI and Oncology as well as all the relevant endpoints. Posters A primary jejunum and primary hepatocyte multi-organ MPS Find out how our gut-liver MPS recapitulates the physiological condition enabling oral drug dosing in vitro. This gut-liver model offers a vast improvement in the methods used to study PK or prodrugs. Articles ADME Studies: Determining Promising Drug Compounds Dr Abbas discusses factors that can affect the outcome of an ADME study, signs that a drug compound shows promise, red flags, and key parameters to determine safety and efficacy. This article is taken from PharmTech, November 2022. Articles How to Keep Breathing – The Future of Inhaled Medication Testing Dr Emily Richardson discusses the current challenges faced to bring inhaled therapeutics to the market and the potential of Organ-on-a-Chip to increase positive outcome by improving ADME drug testing. This article is taken from International Biopharmaceutical Industry, Summer 2022. Videos and animations PhysioMimix Multi-organ System Animation An introduction to the CN Bio PhysioMimix Multi-organ System. This animation demonstrates how our microphysiological system works, how to create a Gut/Liver-on-a-chip model and an example of its use in determining drug Bioavailability in vitro. Posters Why two organs are better than one Abbas, Kostrzewski & Hughes This poster demonstrates how a gut-liver MPS can improve oral bioavailability predictions by mimicking human oral and IV regimens. Thus improving the in vitro to in vivo translation of drug efficacy and safety. Articles Predicting Drug Bioavailability with the Modern-Day Toolkit Animal models continue to be used in bioavailability research but limitations are serious and difficult to overcome. Find out how OOC can help solve your PK/PD and bioavailability issues. This article is taken from International Biopharmaceutical Industry Winter 2021, pages 14-17. Application notes Improved prediction of oral bioavailability using a gut-liver microphysiological system Abbas, Kostrzewski & Hughes Central to the development of new drugs is an understanding of their pharmacokinetic properties, in particular their bioavailability. Here, we demonstrate the potential of a true 2-organ gut-liver MPS to better predict human bioavailability and improve in vitro to in vivo correlation. Webinars From Dose to Circulation: Determination of Drug Oral Bioavailability Using a Gut-Liver Microphysiological System Webinar Series 4 Episode 4 In this webinar, Dr. Yassen Abbas discusses how CNBio’s gut-liver MPS can be used for in vitro determination of oral bioavailability. This application has been validated with drugs with known human bioavailability and with a mathematical model developed to enable prediction of oral bioavailability in silico. Posters Microphysiological systems of the human liver, gut and linked liver-gut, to assess human drug absorption, metabolism and bioavailbility Kostrzewski et al This poster demonstrates the potential of human MPS models for liver, gut, and multi-organ (connecting gut with liver) for the investigation of human PK parameters, drug absorption and metabolism, and bioavailability.