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Why two organs are better than one

June 6, 2022 by

Resource > Posters >

Why two organs are better than one


A gut-liver microphysiological system that mimics human oral and intravenous dosing regimens for improved prediction of oral bioavailability

Filed under: ADME, Drug bioavailability, and General OOC

Why two organs are better than one EDIT |
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Abbas, Kostrzewski & Hughes

The challenge to continuously improve the in vitro to in vivo translation of drug efficacy and safety data has driven the emergence of more complex multi-organ microphysiological systems (MPS) that are fluidically linked (Edington et al., 2018).

Here, we introduce the PhysioMimix Dual-organ plate, with which a gut-liver model was developed for the assessment of first-pass hepatic metabolism, organ-to-organ crosstalk and quantitative ADME parameters such as oral bioavailability. 

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Latest news

  • The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system January 17, 2023
  • The U.S. FDA Modernization Act 2.0. Now the animal testing mandate is removed, learn what can be embraced in its place. January 9, 2023
  • CN Bio appoints Dr Paul Brooks as Chief Executive Officer December 19, 2022

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