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Why two organs are better than one
A gut-liver microphysiological system that mimics human oral and intravenous dosing regimens for improved prediction of oral bioavailability
Filed under: ADME, Drug bioavailability, and General OOC
Abbas, Kostrzewski & Hughes
The challenge to continuously improve the in vitro to in vivo translation of drug efficacy and safety data has driven the emergence of more complex multi-organ microphysiological systems (MPS) that are fluidically linked (Edington et al., 2018).
Here, we introduce the PhysioMimix Dual-organ plate, with which a gut-liver model was developed for the assessment of first-pass hepatic metabolism, organ-to-organ crosstalk and quantitative ADME parameters such as oral bioavailability.