A unique opportunity to measure drug ADME in vitro without using animals
Our in vitro assays are highly predictive of clinical results. Studies investigating drug metabolism, metabolite identification, permeability, and bioavailability are conducted using human highly functional, metabolically competent single- and multi-organ models.
Service overview:
We offer a range of single- and multi-organ models to derive human-relevant data to better inform the selection of lead candidates with desirable ADME properties.
Through this service, you can utilize a combination of our expertise and highly metabolically active, long-term cultures to derive unique in vitro data.
- Hepatic clearance including low clearance compounds and metabolite identification, including Phase I and II metabolites
- Gut metabolism and permeability
- Lung permeability in upper and lower airway models
- Bioavailability prediction using multi-organ models to simulate route of administration
- Method developed with protein-free cell culture medium in conjunction with low non-specific binding multi-chip assay plates
Customer feedback
Working with CN Bio has been a pleasure, the team listened to our non-trivial requirements and made useful suggestions to help meet objectives. During the course of the project, the team were responsive and helpful. The results were delivered as agreed and helped us to move towards our goals.
Dr Giuseppe Ferrandino
Senior Translational Scientist at Owlstone Medical
View more PhysioMimix reviews on SelectScience
How the service works:
Utilizing our PhysioMimix OOC systems allows the modeling of human ADME profiles in liver, gut, lung, or multi-organ combinations.
This in vitro service generates novel insights into the human body’s effect on drugs, previously only possible using animal models.
Your dedicated contact will work collaboratively with you from the start to the end of the project.
- Design and finalize experiment plan
- Customer supplies required amount of drug(s)
- Growth and preparation of organ models prior to treatment – between four and 21 days, dependent on assay selected
- Compound dosing and sample collection over one to four days
- One to two weeks to run endpoint assays, analyze data, and complete the report
- ~ two months to complete the study from receiving order
- Media samples sent to customer, or third party for LC-MS analysis
Standard liver drug metabolism cell culture timeline
Related applications
Featured resources
Scientific publications
Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism and accumulation
Posters
Gut-liver organ-on-a-chip combined with in silico modeling as a promising tool for investigation of mycophenolate mofetil pharmocokinetics
Scientific publications
Exploration and Application of a Liver-on-a-Chip Device in Combination with Modelling and Simulation for Quantitative Drug Metabolism Studies
