Filters Resource type Area of interest Posters Connecting the human intestine and liver A primary jejunum and primary hepatocyte multi-organ MPS for more predictive studies of human drug ADME and oral bioavailability Traditional immortalized intestinal cell lines and suspension hepatocytes have absent or low levels of metabolic enzyme expression, and thus fail to predict first pass human metabolism and oral bioavailability. Efforts to improve the in vitro to in vivo translation of drug efficacy and safety data has led to the emergence of more human relevant microphysiological systems (MPS) that consist of multiple, fluidically linked organs1. Articles Harnessing Microphysiological Systems to Bring Humanized Processes to ADME and Bioavailability Studies Dr. Abbas discusses the common drawbacks of using conventional methods for ADME studies that can misinform the candidate selection process and dosage figures. He talks about how emerging complementary technologies, such as organ-on-a-chip (OOC), offer human-relevant in vitro preclinical data, and how using OOC can support the determination of human bioavailability to support drug dosing regiments, reduce side effects, and potentially recover flawed therapeutic candidates. Brochures & Flyers Organ-on-a-chip Contract Research Services Brochure Discover our full range of Organ-on-a-chip contract research services including ADME, NASH, DILI and Oncology as well as all the relevant endpoints. Posters A primary jejunum and primary hepatocyte multi-organ MPS Find out how our gut-liver MPS recapitulates the physiological condition enabling oral drug dosing in vitro. This gut-liver model offers a vast improvement in the methods used to study PK or prodrugs. Articles ADME Studies: Determining Promising Drug Compounds Dr Abbas discusses factors that can affect the outcome of an ADME study, signs that a drug compound shows promise, red flags, and key parameters to determine safety and efficacy. This article is taken from PharmTech, November 2022. Articles How to Keep Breathing – The Future of Inhaled Medication Testing Dr Emily Richardson discusses the current challenges faced to bring inhaled therapeutics to the market and the potential of Organ-on-a-Chip to increase positive outcome by improving ADME drug testing. This article is taken from International Biopharmaceutical Industry, Summer 2022. Videos and animations PhysioMimix Multi-organ System Animation An introduction to the CN Bio PhysioMimix Multi-organ System. This animation demonstrates how our microphysiological system works, how to create a Gut/Liver-on-a-chip model and an example of its use in determining drug Bioavailability in vitro. Scientific publications Application of a gut–liver-on-a-chip device and mechanistic modeling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil Milani et al., 2022 This study shows how an in vitro gut-liver multi-organ model can quantitatively recapitulate the in vivo metabolism of a drug. By combining Organ-on-a-chip with in silico modeling, the study also demonstrates the potential of multi-organ models for quantitative estimation of PK parameters of a drug and its metabolites. Webinars Every Breath You Take Webinar Series 5 Episode 2 In this webinar, Lead Scientist, Dr Emily Richardson describes novel alveolar and bronchial lung-on-a-chip, or lung MPS, models. She demonstrates how to predict drug pharmacokinetics, allowing for more rapid, precise, and cost-effective compound analysis. Posters Why two organs are better than one Abbas, Kostrzewski & Hughes This poster demonstrates how a gut-liver MPS can improve oral bioavailability predictions by mimicking human oral and IV regimens. Thus improving the in vitro to in vivo translation of drug efficacy and safety. Posters Normalization of organ-on-a-chip samples for mass spectrometry based proteomics and metabolomics via dansylation-based assay Gallagher et al This poster shows the combined use of MS-based proteomics and metabolomics with organ-on-a-chip to better assess the classification of biological replicates in toxicity studies. Posters Harnessing the power of multimodal imaging to explore ASO distribution in cells, complex in vitro models and tissue Alex et al This recent poster from GSK and collaborators features data from our PhysioMimix® OOC and Liver (MPS-LC12) plates. The results demonstrate that the distribution of ASOs into Kupffer cells and circular or cuboidal hepatocytes cultured in 3D can be detected using imaging.