Scientific Publications
Peer-reviewed Scientific Articles
Devices & Systems Biology
Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk
Chen, W. L., Edington C., Suter E., Yu J., Velazquez J. G., Shockley M., Large E. M., Venkataramanan R., Hughes D. J., Stokes C. L., Trumper D. L., Carrier R. L., Cirit M., Griffith L. G. & Lauffenburger D. A. .
Biotechnology and Bioengineering, 2017; 114(11):2648-2659.
doi: 10.1002/bit.26370.
Hughes, D. J., Kostrzewski T. & Sceats, E. L.
Experimental Biology & Medicine, 2017; 242(16):1593-1604.
doi: 10.1177/1535370217708976.
Maass C., Stokes C. L., Griffith L. G. & Cirit, M.
Integr. Biol., 2017; 9(4):290-302.
doi: 10.1039/c6ib00243a.
Yu, J., Clifone N. A., Large E. M., Sarkar U., Wishnok J. S., Tannenbaum S. R., Hughes D. J., Lauffenburger D. A., Griffith L., Stokes C. L. & Cirit M.
CPT: pharmacometrics & systems pharmacology, 2015; 4, 585-594.
doi: 10.1002/psp4.12010.
Bioreactor technologies to support liver function in vitro
Ebrahimkhani, M., Neiman, J., Raredon, M., Hughes, D. & Griffith, L.
Advanced Drug Delivery Reviews, 2014; 69–70, 132-157.
doi: 10.1016/j.addr.2014.02.011.
Perfused multiwell plate for 3D liver tissue engineering.
Domansky K., Inman W., Serdy J., Dash A., Lim M. H. & Griffith, L. G
Lab on a chip, 2010 10 (1), 51-8.
doi: 10.1039/b913221j.
Design, modeling and fabrication of a constant flow pneumatic micropump
Walker, I. et al.
Journal of Micromechanics and Microengineering, 2007; 17 (5), 891.
Pharmacokinetics Drug Metabolism & Toxicology
Rowe C., Shaeri M., Large E. M., Cornforth T., Robinson A., Kostrzewski T., Sison-Young R., Goldring C., Park K. & Hughes D. J.
Toxicology in Vitro, 2018; 46:29-38.
doi: 10.1016/j.tiv.2017.09.012.
Sarkar U., Ravindra K. C., Large E., Young C. L., Rivera-Burgos D., Yu J., Cirit M., Hughes D. J., Wishnok J. S., Lauffenburger D. A., Griffith L. G, Tannenbaum SR.
Drug Metabolism and Disposition, 2017; 45 (7) 855-866.
doi: 10.1124/dmd.116.074005.
Tsamandouras N., Kostrzewski T., Stokes C. L., Griffith L. G., Hughes D. J. & Cirit M.
J Pharmacol Exp Ther, 2017; 360(1): 95-105 [PMID: 27760784
Long T. J., Cosgrove P. A., Dunn R. T., Stolz D. B., Hamadeh H., Afshari C., McBride H. & Griffith L. G.
Drug Metab Dispos 2016; 44(12): 1940-1948 [PMID: 27621203 PMCID: PMC5118635
Vivares A., Salle-Lefort S., Arabeyre-Fabre C., Ngo R., Penarier G., Bremond M., Moliner P., Gallas J. F., Fabre G. & Klieber S.
Xenobiotica, 2015; 45(1): 29-44
doi: 10.3109/00498254.2014.944612.
Sarkar U., Rivera-Burgos D., Large E. M., Hughes D. J., Ravindra K. C., Dyer R. L., Ebrahimkhani M. R., Wishnok J. S., Griffith L. G. & Tannenbaum S. R.
Drug Metabolism and Disposition, 2015; 43, 1091-1099.
doi: 10.1124/dmd.115.063495.
Disease Models
A Microphysiological System for Studying Nonalcoholic Steatohepatitis
Kostrzewski T., Maraver P., Ouro‐Gnao L., Levi A., Snow S., Miedzik A., Rombouts K. & Hughes D.
Hepatology Communications, 2019.
doi: 10.1002/hep4.1450
3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
Ortega-Prieto A. M., Skelton J. K., Wai S. N., Large E., Lussignol M., Vizcay-Barrena G., Hughes D, Fleck R. A., Thursz M., Catanese M. T. & Dorner M.
Nature Communications 2018; 14;9(1):682.
doi: 10.1038/s41467-018-02969-8.
Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk
Chen, W. L., Edington C., Suter E., Yu J., Velazquez J. G., Shockley M., Large E. M., Venkataramanan R., Hughes D. J., Stokes C. L., Trumper D. L., Carrier R. L., Cirit M., Griffith L. G. & Lauffenburger D. A. .
Biotechnology and Bioengineering, 2017; 114(11):2648-2659.
doi: 10.1002/bit.26370.
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease
Kostrzewski T., Cornforth T., Snow S. A., Ouro-Gnao L., Rowe C., Large E. M. & Hughes D. J.
World Journal of Gastroenterology 2017; 23(2): 204-215
doi: 10.3748/wjg.v23.i2.204.
Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system
Wheeler S. E., Clark A. M., Taylor D. P., Young C. L., Pillai V. C., Stolz D. B., Venkataramanan R., Lauffenburger D., Griffith L. & Wells A.
Br J Cancer 2014; 111(12): 2342-2350 [PMID: 25314052 PMCID: PMC4264444
doi: 10.1038/bjc.2014.533.
Multi-Organ Systems
Tsamandouras N., Chen W. L. K., Edington C. D., Stokes C. L., Griffith L. G. & Cirit M.
AAPS J, 2017; 19: 1499.
doi: 10.1208/s12248-017-0122-4
Maass C., Dallas M., LaBarge M. E., Shockley M., Valdez J., Geishecker E., Stokes C. L., Griffith L. G. & Cirit M.
Scientific Reports, 2018; 8(1):8015.
doi: 10.1038/s41598-018-25971-y.
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
Edington C. D., Chen W. L. K., Geishecker E., Kassis T., Soenksen L. R., Bhushan B. M., Freake D. , Kirschner J., Maass C., Tsamandouras N., Valdez J., Cook C. D., Parent T., Snyder S., Yu J., Suter E., Shockley M., Velazquez J., Velazquez J. J., Stockdale L., Papps J. P., Lee I., Vann N., Gamboa M., LaBarge M. E., Zhong Z., Wang X., Boyer L. A., Lauffenburger D. A., Carrier R. L., Communal C., Tannenbaum S. R., Stokes C. L., Hughes D. J., Rohatgi G., Trumper D. L., Cirit M. & Griffith L. G.
Nature Scientific Reports, 2018; 4;8(1):4530.
doi: 10.1038/s41598-018-22749-0.
Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk
Chen, W. L., Edington C., Suter E., Yu J., Velazquez J. G., Shockley M., Large E. M., Venkataramanan R., Hughes D. J., Stokes C. L., Trumper D. L., Carrier R. L., Cirit M., Griffith L. G. & Lauffenburger D. A. .
Biotechnology and Bioengineering, 2017; 114(11):2648-2659.
doi: 10.1002/bit.26370.
Maass C., Stokes C. L., Griffith L. G. & Cirit, M.
Integr. Biol., 2017; 9(4):290-302.
doi: 10.1039/c6ib00243a.
Yu, J., Clifone N. A., Large E. M., Sarkar U., Wishnok J. S., Tannenbaum S. R., Hughes D. J., Lauffenburger D. A., Griffith L., Stokes C. L. & Cirit M.
CPT: pharmacometrics & systems pharmacology, 2015; 4, 585-594.
doi: 10.1002/psp4.12010.
Scientific Conference Poster Presentations
Tomasz Kostrzewski, Paloma Maraver, Sophie Snow, Ana Levi, Kareene Smith, Krista Rombouts and David Hughes
Alysha Bray, Dharaminder Singh, Kareene Smith, David Hughes, Tomasz Kostrzewski
Tomasz Kostrzewski, Sophie Snow, Anya Lindstrom Battle, Samantha Peel, Zahida Ahmad, Jayati Basak, Daniel Lindén, Christian Maass, Andrzej Kierzek, Kareene Smith, Piet van der Graaf, Lorna Ewart and David Hughes.
Annette Dalrymple, Tomasz Kostrzewski, Paloma Maraver, Sarah Corke, David Hughes, Marianna Gaca
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