Scientific Publications

Peer-reviewed Scientific Articles

Devices & Systems Biology

Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk

Chen, W. L. et al.
Biotechnology and Bioengineering, 2017.

Opportunities and Challenges in the wider adoption of liver and interconnected microphysiological systems

Hughes, DJ, Kostrzewski T, Sceats, EL
Experimental Biology & Medicine, 2017.

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

Maass C, Stokes CL, Griffith LG, Cirit, M.
Integr. Biol., 2017,9, 290-302

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration

Yu, J. et al.
CPT: pharmacometrics & systems pharmacology 4, 585-594 (2015).

Bioreactor technologies to support liver function in vitro

Ebrahimkhani, M., Neiman, J., Raredon, M., Hughes, D. & Griffith, L.
Advanced Drug Delivery Reviews 69–70, 132-157 (2014).

Perfused multiwell plate for 3D liver tissue engineering.

Domansky, K.; Inman, W.; Serdy, J.; Dash, A.; Lim, M. H.; Griffith, L. G
Lab on a chip 10 (1), 51-8 (2010)

Design, modeling and fabrication of a constant flow pneumatic micropump

Walker, I. et al.
Journal of Micromechanics and Microengineering 17 (5), 891 (2007)

Pharmacokinetics Drug Metabolism & Toxicology

Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins

Rowe C, Shaeri M, Large EM, Cornforth T, Robinson A, Kostrzewski T, Sison-Young R, Goldring C, Park K, Hughes DJ.
Toxicology in Vitro. 2017.

Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a 3D human liver-immunocompetent co-culture system

Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR.
Drug Metabolism and Disposition. 2017, 45 (7) 855-866.

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

Tsamandouras N, Kostrzewski T, Stokes CL, Griffith LG, Hughes DJ, Cirit M.
J Pharmacol Exp Ther 2017; 360(1): 95-105 [PMID: 27760784

Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform.

Long TJ, Cosgrove PA, Dunn RT, 2nd, Stolz DB, Hamadeh H, Afshari C, McBride H, Griffith LG.
Drug Metab Dispos 2016; 44(12): 1940-1948 [PMID: 27621203 PMCID: PMC5118635

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.

Vivares A, Salle-Lefort S, Arabeyre-Fabre C, Ngo R, Penarier G, Bremond M, Moliner P, Gallas JF, Fabre G, Klieber S.
Xenobiotica 2015; 45(1): 29-44 [PMID: 25068923

Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Sarkar, U. et al.
Drug Metabolism and Disposition 43, 1091-1099 (2015)

Disease Models

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

A.M. Ortega-Prieto, J. K. Skelton, S. N. Wai, E. Large, M. Lussignol, G. Vizcay-Barrena, D. Hughes, R. A. Fleck, M. Thursz, M. T. Catanese & M. Dorner
Nature Communications 2018

Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk

Chen, W. L. et al.
Biotechnology and Bioengineering, 2017.

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

Kostrzewski T, Cornforth T, Snow SA, Ouro-Gnao L, Rowe C, Large EM, Hughes DJ.
World Journal of Gastroenterology 2017; 23(2): 204-215

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

Wheeler SE, Clark AM, Taylor DP, Young CL, Pillai VC, Stolz DB, Venkataramanan R, Lauffenburger D, Griffith L, Wells A
Br J Cancer 2014; 111(12): 2342-2350 [PMID: 25314052 PMCID: PMC4264444

Multi-Organ Systems

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Tsamandouras, N., Chen, W.L.K., Edington, C.D. et al.
AAPS J (2017) 19: 1499.

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies

Christian Maass, Matthew Dallas, Matthew E. LaBarge et al
Scientific Reports volume 8, Article number: 8015 (2018)

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Collin D. Edington, Wen Li Kelly Chen, Emily Geishecker et al.
Nature 2018

Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk

Chen, W. L. et al.
Biotechnology and Bioengineering, 2017.

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

Maass C, Stokes CL, Griffith LG, Cirit, M.
Integr. Biol., 2017,9, 290-302

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration

Yu, J. et al.
CPT: pharmacometrics & systems pharmacology 4, 585-594 (2015).

Scientific Conference Poster Presentations

The Characterisation of a Human Two Organ-on-a-Chip (Lung-Liver) System which has the Potential to Measure Systemic Responses In Vitro

Annette Dalrymple, Tomasz Kostrzewski, Paloma Maraver, Sarah Corke, David Hughes, Marianna Gaca

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Fully human in vitro gut-liver model of non-alcoholic steatohepatitis

Tomasz Kostrzewski, Paloma Maraver, Mohsen Shaeri, Sophie Snow, and David Hughes.

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The PNPLA3 I148M variant enhances the disease phenotype of hepatic stellate cells in an in vitro model of non-alcoholic fatty liver disease

Tomasz Kostrzewski, Paloma Maraver, Ana Levi, Kareene Smith, Krista Rombouts and David Hughes

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Microphysiological systems for studying interactions between the liver, gut and immune system

Tomasz Kostrzewski, Mohsen Shaeri, Larissa Ouro-Gnao, Sophie Snow, Kareene Smith, Paloma Maraver and David Hughes

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Identification And Evaluation Of Patient Serum Isolates As A Source Of Inoculum For 3D In Vitro Cell Culture: A Tool For Drug Discovery

E. Large, C. Smith Burchnell, J. Malone, S. Snow, S. Wildum and D. Hughes

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Three-dimensional perfused cell culture enhances the infectability of primary human hepatocytes with Hepatitis B virus

T. Kostrzewski, E. Large, C. Smith Burchnell, M. Shaeri, S. Snow, and D. Hughes

Size 289 KB

Three-dimensional human cell culture model for studying Non-Alcoholic Fatty Liver Disease

Tomasz Kostrzewski, Terri Cornforth, Mohsen Shaeri, Sophie Snow, Larissa Ouro and David Hughes

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Investigating the PK/PD/efficacy relationship of PI3K inhibitors in vitro, enabled by a microfluidic addition and removal device

Dharaminder Singh, Paul Golby, Alysha Bray, Tomasz Kostrzewski, David Hughes

Size 1 MB

In vitro assessment of combination dosing regimens with in vivo like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device

Paul Golby, Dharaminder Singh, Edoardo Buffa, Tomasz Kostrzewski, David Hughes

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