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Introducing the new PhysioMimix Single-Organ Higher Throughput System

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Organ-on-a-Chip Resources

Resource type

Area of interest

Application notes

Resource image

Microphysiological system for studying fatty liver disease and its impact on drug-induced liver injury

Kostrzewski et al

As a result of the increased prevalence of diabetes, obesity, and metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease in developed countries. Using better in vitro models to fast-track therapeutic development but also accurately assess DILI risk in NASH patients ahead of the clinic is critical. Here, we show the potential of an in vitro 3D NASH model to accurately identify any DILI-associated risks.

Scientific publications

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Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

Trapecar et al., 2020

A multi-organ model of ulcerative colitis connecting the gut, liver and circulating Treg and Th17 cells. By integrating immune cells, the effect of microbiome-derived short-chain fatty acids on inflammatory bowel disease can be studied.

Scientific publications

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Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism and accumulation

Rubiano et al., 2020

This study demonstrated the ability of the CN Bio’s PhysioMimix liver model to generate reproducible results from experiments assaying metabolism, drug toxicity and intracellular accumulation. The results from the paper showed that the liver MPS can be routinely used in general drug evaluation applications.

Videos and animations

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Predicting the future: humanised drug evaluation testing using organ-on-a-chip technology

CN Bio’s mission is to transform drug discovery through the development of disruptive single and multi-organ microphysiological systems (MPS) -otherwise known as organ-on-a-chip – that optimize the accuracy and efficiency of bringing new medicines to market.

Scientific publications

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Integrated gut and liver microphysiological systems for quantitative in vitro pharmacokinetics studies

Tsamandouras et al., 2017

There is a need for more physiologically-relevant in vitro models to better investigate the efficacy and pharmacokinetics (PK) of compounds in the early stages of drug development. Here, we demonstrate the potential of a multi-organ (gut-liver) MPS combined with quantitative mechanistic modeling to accurately assess the PK of new therapeutics.

Scientific publications

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Integrated assessment of diclofenac biotransformation, pharmacokinetics and omics-based toxicity in a 3D human liver-immunocompetent co-culture system

Sarkar et al., 2017

The paper demonstrates how 3D liver MPS may serve as preclinical investigational platforms for the discovery of a set of clinically-relevant biomarkers, including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.

Scientific publications

Resource image

Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk

Chen et al., 2017

Animal models are the only way to understand the complex systemic effects of drugs in organisms; however, they often fail to translate to humans. Here, we demonstrate the potential of a multi-organ model to study inflammatory organ crosstalk between the gut and liver.

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Latest news

  • Immune-mediated DILI – Predicting the unpredictable! March 16, 2023
  • CN Bio appoints Deepak Singh as Vice President of Sales and Marketing March 14, 2023
  • CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System   February 27, 2023

Upcoming events

MPS World Summit 2023 June 26-30, 2023

SLAS Europe 2023 May 22-26, 2023

SOT 2023 March 19-23, 2023

WORD 2023 March 22, 2022