WEBINAR: How to set yourself up for success with organ-on-a-chip

Available to watch on-demand now

cnb937 ooc success webinar promo bar v1 |
Watch webinar
cn-bio-organ-on-a-chip-logo cn-bio-organ-on-a-chip-logo cn-bio-organ-on-a-chip-logo cn-bio-organ-on-a-chip-logo
  • Products
    • Explore our solutions


      PhysioMimix® products enable you to recreate complex human biology and accurately predict human drug responses

      PhysioMimix OOC

      PhysioMimix OOC systems
      Learn more

      Consumables

      • Multi-chip plates
      • 3D validated cells
      • NASH-in-a-box
      Learn more

      Models

      • Single-organ models
      • Liver-on-a-chip model
      • Multi-organ models

      Support packages

      • PhysioMimix® support packages
  • Applications
    • Discover the applications


      Investigate the application areas that our PhysioMimix® products and services support

      Learn more

      Disease modeling

      • Non-Alcoholic Steatohepatitis
      • Hepatitis B
      • COVID-19
      Learn more

      Safety toxicology

      • Drug-induced liver injury
      • Immune-mediated toxicities
      Learn more

      ADME

      • Drug absorption
      • Drug metabolism
      • Drug bioavailability
      Learn more
  • Services
    • Studies as a service


      Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

      Learn more
      NAFLD / NASH icons

      NAFLD / NASH

      Drug-induced liver injury icon

      Drug-induced liver injury

      icon adme |

      ADME

  • Resources
  • Company
    • About us


      Meet the team, explore our culture and discover what to expect when working with us

      CN Bio team photo
      About us

      Latest news

      • PhysioMimix data supports Inipharm’s INI-822 for metabolic liver disease treatment

      • OBN Awards 2023 winner!

      • CN Bio appoints Neil Rumbelow as Director of Product Development

      View all news

      Upcoming Events

      Check back soon for upcoming events

      View all events

      Join the team!

      • Director of Sales – Americas Region

      View all jobs
  • Contact
  • Products
    • PhysioMimix® OOC Microphysiological Systems
    • Consumables
      • PhysioMimix® multi-chip plates
      • 3D validated cells
      • NASH-in-a-box
    • Organ-on-a-chip models
    • Support packages
  • Applications
    • Disease modeling
    • Safety toxicology
    • ADME
  • Services
    • Non-Alcoholic Steatohepatitis
    • Drug-Induced Liver Injury
    • ADME
  • Resources
  • Company
    • About us
    • Events
    • News
    • Careers
  • Contact
  • Skip to main content
  • Skip to footer
Chat live with an expert

Comparing an in vitro Organ-on-Chip model of Non-Alcoholic Steatohepatitis to murine models and liver tissue from patients

August 11, 2019

Resource > Posters >

Comparing an in vitro Organ-on-Chip model of Non-Alcoholic Steatohepatitis to murine models and liver tissue from patients


American Association for the Study of Liver Diseases (AASLD)

Filed under: Disease modeling and NAFLD/NASH

Comparing an in vitro organi on a chip model of NASH to murine models EDIT |
Access resource

Kostrzewski et al

As a result of the increased prevalence of diabetes, obesity, and metabolic syndrome, Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most common chronic liver disease in developed countries. NAFLD is a spectrum of pathologies ranging from benign hepatic steatosis through to Non-Alcoholic Steatohepatitis (NASH), which can ultimately lead to cirrhosis and liver cancer. NASH is a serious condition, defined as a combination of hepatic steatosis, inflammation, hepatic damage, and pericellular liver fibrosis. There are currently no FDA-approved drugs for the treatment of NAFLD/NASH and there is a clear requirement for better models to understand this disease. ​

Currently available preclinical models, be it in vivo or in vitro, have a range of limitations and do not fully represent the key aspects of the human disease state. In particular, many preclinical rodent models have been developed, but no individual model fully recapitulates the human disease and significant differences exist in the transcriptomic profile of the liver tissue, the manner in which triglycerides accumulate within the liver, and the level of hepatic fibrosis. Studying NASH using advanced human in vitro models offers the ability to perform studies at the cellular level allowing molecular mechanisms to be elucidated and the genetic drives of the disease to be specifically explored. We have investigated here a fully human in vitro NASH model as a potential solution to improve disease understanding.

Access resource

Speak to our experts

Speak directly with one of our OOC experts to see how our products and services can support your studies

Request a meeting

Footer

CN Bio logo

332 Cambridge Science Park, Milton Road
Cambridge, CB4 0WN

UK: +44 (0) 1223 737 941

US: +1 415 523 4005

Privacy | Cookies | Terms | Regulatory | Accessibility

Product Recycling

©2023 CN Bio Innovations Ltd
Registered No. ‍06517359. VAT No. GB978184563

Latest news

  • PhysioMimix data supports Inipharm’s INI-822 for metabolic liver disease treatment December 4, 2023
  • OBN Awards 2023 winner! November 23, 2023
  • CN Bio appoints Neil Rumbelow as Director of Product Development November 2, 2023

Upcoming events