Liver-On-a-Chip

The liver is a key organ in the study of drug metabolism and toxicology. Understanding the way in which a drug is processed by the liver and discovering any adverse effects is a crucial part of drug development. Liver disease is also a major concern, with approximately 850 million people worldwide living with chronic liver diseases.

CN Bio has developed a Liver-on-a-Chip specifically designed for the research of drug metabolismtoxicology and liver diseases.

Liver Cell Model

CN Bio’s multi-well PhysioMimix™ Liver-on-a-Chip (MPS-LC12) consumable plates are ideally suited to primary liver cell culture and co-culture assays. They enable researchers to identify liver toxicity markers, model liver disease and study drug metabolism.

Our Microphysiological System (MPS) uses scaffolds to create microtissues that are continuously perfused to provide nutrients, oxygen and mechanical stimuli. This enables the extended maintenance (> four weeks) of highly metabolically active, phenotypically intact three-dimensional (3D) primary human hepatocyte cells from which highly reproducible results can be generated.

Liver MPS vs Other models

 

FDA collaboration

Read more in our co-publication with the FDA which demonstrates the advantages of PhysioMimix™ and its Liver-MPS for drug safety and metabolism applications.

PhysioMimix™ Liver-on-a-Chip (MPS-LC12) consumable plates are designed to provide optimal perfused 3D cell culture conditions for:

  • Primary hepatocytes and non-parenchymal cells (human, or preclinical animal species)
  • Stem cell-derived hepatocytes
  • Precision-cut tissue slices
  • Organoids and spheroids
  • Immortalised cell lines

Multi-organ Liver Models

CN Bio’s PhysioMimix Multi-Organ MPS and multi-well MPS-TL6 consumable plates enable our best-in-class liver-on-a-chip model to be interconnected to another organ in the body, such as gut, or lung Barrier Models to study reactive metabolite driven toxicity, whilst simultaneously evaluating drug absorption and metabolism.

Related content

SCIENTIFIC PAPER

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Download paper

SCIENTIFIC PAPER

Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk

Download paper

APPLICATION NOTE

Drug metabolismin a gut-liver microphysiological system

Download Application note

Human organ
mimics

Powerful new
data

Translatable
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