• Skip to main content
  • Skip to primary sidebar
  • Skip to footer
  • About us
  • News
  • Events
  • Careers
cn-bio-organ-on-a-chip-logo
  • Products
    • PhysioMimix® OOC Microphysiological Systems
    • Consumables
      • PhysioMimix® multi-chip plates
      • 3D validated cells
      • NASH-in-a-box
    • Organ-on-a-chip models
    • Gut/Liver-on-a-chip
    • Lung-on-a-chip
    • Support packages
  • Applications
    • Disease modeling
    • Safety toxicology
    • ADME
  • Services
    • Non-Alcoholic Steatohepatitis
    • Drug-Induced Liver Injury
    • ADME
  • Technology
  • Resources
  • Company
    • About us
    • Events
    • News
    • Careers in Biotech
  • Contact us

Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix OOC

physiomimix-single-and-multi-organ-on-a-chip-systems
Learn more

Consumables

Multi-chip plates
3D validated cells
NASH-in-a-box
Bioavailability assay kit: Human 18
DILI assay kit: Human 24
Learn more

Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Discover the applications


Investigate the application areas that our PhysioMimix® products and services support

Learn more

Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
Learn more

Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
Learn more

ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
Learn more

Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

Learn more
icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

CN Bio licenses human gut organ microbiome modelling tool from MIT and Northeastern University

July 27, 2021

GuMI mit pr 1 | gut organ

  • Enables accurate modelling of the human colon and the mucosal barrier
  • Provides new insights to the relationship between human microbiome and effect on human health
  • Model to be integrated into CN Bio’s PhysioMimix® OOC range of single- and multi-organ microphysiological systems

Cambridge, UK, 27 July 2021: CN Bio, a leading Organ-on-a-chip Company (OOC) that designs and manufactures single- and multi-organ microphysiological systems (MPS), today announced it has secured the licensing rights to a novel tool for modelling the gut microbiome, GuMI, from Massachusetts Institute of Technology (MIT) and Northeastern University. Planned for commercial launch in 2023, the technology will be integrated into CN Bio’s PhysioMimix OOC range of single- and multi-organ MPS, enabling researchers to investigate the direct interaction between the microbiome and gut, and the wider effects of the microbiome on organs such as the liver and brain.

The ability to study the human microbiome and its effects on human health is an area of great research interest and a pivotal application for OOC technology. Through its relationship with MIT, CN Bio has licensed the GuMI device from OOC pioneer and long-term collaborator, Professor Linda Griffith, at MIT’s Department of Biological Engineering, whose group recently published findings using the system1, and joint patent-holder Professor Rebecca Carrier at Northeastern University.

Modelling the human microbiome in the laboratory is challenging, especially since many of its several thousand strains of bacteria cannot grow or survive when exposed to oxygen. Animal and in vitro cell-based models have provided some insights to this area of research, however, until now, there has not been a system for long-term in vitro co-culture of a colonic mucosal barrier that supports the growth of these highly oxygen-sensitive microbes.

The GuMI device enables researchers to precisely control oxygen levels within the system, enabling anaerobic bacteria to grow in the mucus layer above the gut barrier. This closely resembles human physiology. Micropumps circulate cell culture medium to ensure the cells are nourished and to remove bacteria from the system for specific analysis of the microbiome.

This agreement follows the recent selection of CN Bio’s PhysioMimix® Multi-Organ MPS by King’s College London, to create a unique human-relevant liver-intestinal model for characterizing and manipulating host-microbial interactions, to support improved outcomes in cirrhosis2.


Dr David Hughes, CEO, CN Bio, commented: “We are rapidly coming to appreciate the important role the microbiome plays in human health and disease. The field is held back by a lack of experimental systems which truly enable researchers to explore and understand the microbiome and its interactions. Adding the GuMI technology to our PhysioMimix system is an important step in CN Bio’s journey to providing our customers with the most physiologically relevant models to power their drug discovery.”    


For future details on the PhysioMimix single- and multi-organ systems, please visit:

https://cn-bio.com/physiomimixooc/


To learn more watch the following webinar on demand:

Engineering Mucosal Barriers

From Organoids to Organs-on-Chips with Professor Linda Griffith, S.E.T.I. Professor of Biological and Mechanical Engineering Research
Director of the Center for Gynepathology Research at MIT

  1. Zhang J et al., Primary Human Colonic Mucosal Barrier Crosstalk with Super Oxygen-Sensitive Faecalibacterium prausnitzii in Continuous Culture. Med 2021; 2(1): 74-98e.9
  2. CN Bio’s PhysioMimix® adopted by King’s College London to investigate chronic liver disease (29th June 2021) https://cn-bio.com/cn-bios-physiomimix-adopted-by-kings-college-london-to-investigate-chronic-liver-disease/

Category iconPress releases

Primary Sidebar

Other recent news

  • CN Bio introduces cross-species DILI services to enhance in vitro to in vivo extrapolation during preclinical drug development June 10, 2025
  • CN Bio expands access to OOC solutions for APAC customers with distributor agreement in South Korea May 20, 2025
  • Microphysiological systems for mAbs development: how do they address animal limitations? May 1, 2025
  • Why the FDA animal testing phase-out for monoclonal antibodies? May 1, 2025
  • NIH to prioritize human-based research technologies & reduce animal use in research April 29, 2025

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

Request a meeting

Footer

CN Bio logo

332 Cambridge Science Park, Milton Road
Cambridge, CB4 0WN

UK: +44 (0) 1223 737 941

US: +1 415 523 4005

Privacy | Cookies | Regulatory | Accessibility
Website terms | Terms of sale

Product Recycling

©2025 CN Bio Innovations Ltd
Registered No. ‍06517359. VAT No. GB978184563

Latest news

  • CN Bio introduces cross-species DILI services to enhance in vitro to in vivo extrapolation during preclinical drug development June 10, 2025
  • CN Bio expands access to OOC solutions for APAC customers with distributor agreement in South Korea May 20, 2025
  • Microphysiological systems for mAbs development: how do they address animal limitations? May 1, 2025
Cyber Essentials Logo