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Chat live with an expert

Testing on Humans

January 9, 2021 by

Resource > Webinars >

Testing on Humans


How to Predict Hepatotoxicity and Drug Clearance Ahead of Clinical Trials Using Liver-on-a-Chip

Filed under: ADME, Disease modeling, Drug metabolism, and Safety toxicology

web s2e2 |

Video content if present

Current in vitro approaches for investigational toxicology, drug metabolism (DMPK) and safety are limited.


Furthermore, they are not fully representative of human response; therefore, drugs showing acceptable preclinical toxicity often fail in human clinical trials, and accurately predicting human drug exposure for new compounds is challenging and costly.

Watch this webinar to learn:

  • Developing liver-on-chip MPS systems and comparison to traditional in vitro liver approaches
  • Modeling human hepatotoxicity prediction using liver-MPS
  • Modeling human drug clearance using liver-MPS
  • Data validating and translatability between organ-on-chips and human
  • Accessing CN Bio MPS technology

Microphysiological Systems (MPS), or Organ-on-chip (OOC) technologies are a trending way to bridge the gap between traditional DMPK/toxicology assays and human trials by providing more robust and reliable data that translate into clinical outcomes.

CN Bio offers preclinical investigational toxicology and DMPK services using its proprietary, industry-proven PhysioMimix™ OOC technology and liver-on-a-chip model. In this webinar, we will share our latest advances in investigational toxicology, drug clearance and drug safety, highlighting how the translatable, human-relevant data generated using CN Bio’s liver-on-a-chip model can be used to support (or call into question) the conclusions of internal pre-clinical studies, helping you to make data driven decisions with greater confidence.


Speaker Information:

Dr Tomasz KostrzewskiDr Tomasz Kostrzewski

VP – Science & Technology
CN Bio

Video content if present

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Latest news

  • The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system January 17, 2023
  • The U.S. FDA Modernization Act 2.0. Now the animal testing mandate is removed, learn what can be embraced in its place. January 9, 2023
  • CN Bio appoints Dr Paul Brooks as Chief Executive Officer December 19, 2022

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