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Discover the applications


Investigate the validated core application areas that our PhysioMimix® products and services support

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Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
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Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
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ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
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Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

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icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix Core

cnb1476_physiomimix-core_mark_mocks_system_v2
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Consumables

Multi-chip plates
3D validated cells
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Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Blog

September 5, 2023

A guide to pre-validating primary cells for use in Organ-on-a-chip assays

Mirror, mirror on the wall, which is the best cell of them all? If you are considering incorporating Organ-on-a-chip (OOC) technology into your

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March 16, 2023

Immune-mediated DILI – Predicting the unpredictable!

Different types of Drug-induced Liver Injury (DILI) Drug-induced liver injury (DILI) is a longstanding and significant problem for clinicians,

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January 9, 2023

The U.S. FDA Modernization Act 2.0. Now the animal testing mandate is removed, learn what can be embraced in its place.

What is the FDA Modernization Act 2.0, and what does it mean? The U.S. Food and Drug Administration (FDA) are the federal agency tasked with

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June 27, 2022

MPS World Summit round-up 2022

  If you could not attend the inaugural Microphysiological System (MPS) World Summit in New Orleans earlier this month, but it is on your radar for

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March 23, 2022

The lung in crisis: fighting back against pathogens, infections and inflammation with predictive in vitro lung models that accelerate drug discovery

The human lung is in crisis Our lungs represent the only internal organ that is directly subject to the environment and therefore face a relentless

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February 24, 2022

Debunking the 9 myths of Organ-on-a-chip technology

Organ-on-a-chip (OOC) technology offers you a transformative approach to better science. By bridging the gaps between traditional cell culture, animal

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December 7, 2021

De-risking drug-induced liver injury through the predictive power of organ-on-a-chip

The liver is responsible for metabolizing most medications, and as such represents one of the primary tissues affected by adverse drug reactions.

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July 15, 2021

Of Mice and Men – Will human organ-on-a-chip disease models replace animal use?

The aim of organ-on-a-chip (OOC) technology is to more accurately replicate human physiology in vitro to overcome the relevance limitations of current

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April 21, 2021

NAFLD vs MASLD: could a name change impact the progression of liver disease research?

Liver disease is a serious worldwide problem linked to approximately two million deaths per year and in many cases is entirely preventable (Sumeet et

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Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • Organ-on-a-chip trends shaping the next phase of human-relevant R&D from the MPS World Summit 2026 July 6, 2026
  • Which microphysiological system contexts of use are aligned with regulatory roadmaps? June 2, 2026
  • A new era of drug development: Comparing regulatory roadmaps to reduce animal testing June 2, 2026
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