Preclinical toxicology Studies

Preclinical testing traditionally occurs in simple cell culture systems or animal models to provide data about a drug’s safety and efficacy before human testing begins. However drugs that show acceptable toxicity in these systems will often fail in human trials due to adverse effects.
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Toxicology Studies using PhysioMimix™

PhysioMimix™ Organ-on-Chip technology allows scientists to test new drug therapies and detect possible side effects in a human relevant system before the drugs are tested in humans. Our system can be used to research whether a  drug intended to treat one organ will have adverse effects on another and the effect of human specific drug metabolites on organ toxicity.

This data showing how the body interacts with a new drug (pharmacokinetics and ADME studies) supports more accurate prediction and management of risks during the pre-clinical testing phase.

Liver Toxicology

Liver toxicity is a major safety concern during drug development. It causes pharmaceutical companies to halt the development of new medicines — sometimes after spending hundreds of millions of dollars on clinical trials to establish the drug’s safety and effectiveness.

CN Bio’s PhysioMimix™ Liver-on-Chip is designed to improve preclinical testing and identify liver toxicity early. It does this by allowing researchers to recapitulate the physiological and mechanical microenvironment of the liver.

FDA Collaboration

CN Bio is collaborating with the US FDA (Food and Drug Administration), focussing on evaluating data, systems and models to predict liver toxicity and drug safety.

Liver toxicity is one of the most common causes of adverse side effects, preventing drugs from successfully completing clinical trials or leading to their withdrawal from the marketplace.

Human organ
mimics

Powerful new
data

Translatable
results

COMPANY HEAD OFFICE INFORMATION:

CN Bio Innovations Limited
BioPark Hertfordshire
Broadwater Road
Welwyn Garden City
Hertfordshire
AL7 3AX, UK

+44 (0) 1707 358 739
enquiries@cn-bio.com

FOR PRODUCT, SERVICES AND MARKETING ENQUIRIES:

enquiries@cn-bio.com
+44 (0) 1707 358 739

CN BIO INNOVATIONS LIMITED REGISTERED OFFICE:

30 Upper High Street, Thame,
Oxfordshire, OX9 3EZ.

Registered No. 06517359.
VAT No. 978184563


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