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Predictive DILI Models: Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity

September 9, 2021 by

Resource > Webinars >

Predictive DILI Models: Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity


For Studying Acute and Chronic Drug-Induced Liver Toxicity

Filed under: DILI, Disease modeling, and Safety toxicology

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Video content if present

Predictive DILI models

Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity


Watch this webinar to learn:

  • Discover how the liver MPS can be used to detect mild through to severe DILI toxicants
  • Understand how MPS can be used to generate mechanistic signatures of hepatotoxicity
  • Enable your scientists to reduce drug attrition in the early phases of clinical trials

In this webinar, CN Bio Senior Scientist Dr Ovidiu Novac discusses how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

With safety concerns being the major cause for failures in phase 1/2 clinical trials, developing more predictive models within preclinical drug discovery is essential to improve data translatability.

In this webinar, CN Bio Senior Scientist Dr Ovidiu Novac will discuss how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

Ovidiu will discuss how his team validated the MPS using a broad set of mild to severe hepatotoxic compounds and how the MPS delivered novel insights not previously seen in vitro.


View our Q&A document from the live event.


Speaker Information:

oviDr Ovidiu Novac

Senior Scientist
CN Bio

Video content if present

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Latest news

  • Immune-mediated DILI – Predicting the unpredictable! March 16, 2023
  • CN Bio appoints Deepak Singh as Vice President of Sales and Marketing March 14, 2023
  • CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System   February 27, 2023

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