Predictive DILI models

Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity

Watch this webinar to learn:

• Discover how the liver MPS can be used to detect mild through to severe DILI toxicants
• Understand how MPS can be used to generate mechanistic signatures of hepatotoxicity
• Enable your scientists to reduce drug attrition in the early phases of clinical trials

In this webinar, CN Bio Senior Scientist Dr Ovidiu Novac discusses how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

With safety concerns being the major cause for failures in phase 1/2 clinical trials, developing more predictive models within preclinical drug discovery is essential to improve data translatability.

In this webinar, CN Bio Senior Scientist Dr Ovidiu Novac will discuss how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

Ovidiu will discuss how his team validated the MPS using a broad set of mild to severe hepatotoxic compounds and how the MPS delivered novel insights not previously seen in vitro.

View our Q&A document from the live event.

Speaker Information:

Dr Ovidiu Novac

Senior Scientist
CN Bio