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A Microphysiological Model of Metastatic Progression
Using systems to model metastatic progression
Filed under: Disease modeling and Oncology
In this webinar, we discuss how to use systems to model metastatic progression, evaluate therapeutics and improve our understanding of the bidirectional crosstalk that occurs between host tissue cells and the metastatic cancer cells.
Watch this webinar to learn:
- How to model dormant-emergent metastatic progression
- The impact of scaffolding materials on the metastatic niche and therapeutic efficacy
- The impact of Organ-on-a-Chip technologies on our understanding of:
– bidirectional crosstalk between parenchymal cells
– metastatic tumor cells
Metastatic disease is the leading cause of mortality in patients with solid tumors. Despite decades of research, we only partially understand the underlying cellular and molecular mechanisms.
This gap in knowledge represents a significant barrier for the prevention and treatment of metastasis. In part, a lack of relevant accessible model systems capable of capturing the complexities of metastatic disease progression has hindered our progress. As a result, researchers are turning towards tissue engineered ex vivo biomimetic microphysiological systems.
Dr Amanda Clark
Research Assistant Professor
University of Pittsburgh