Barrier Models

CN Bio’s MPS T12 plate can be used with the addition of Transwell® inserts giving the ability to perform barrier model studies. This creates a simple and adaptable MPS for modelling single cell barriers through to complex co-culture systems.

The platform allows for models to be developed replicating specific barriers such as the gut, lung or skin with microfluidic perfusion generating a physiologically relevant microenvironment.

CN Bio’s barrier models can be used to study drug absorption, localised and systemic toxicity and disease. They are ideally suited for a range of cell types, including primary cells, stem cells or immortalised cell lines.

Gut-on-a-Chip

Our MPS-T12 plate can be used as a Gut-on-a-Chip device, modelling the gut barrier. It recapitulates the physiological and mechanical microenvironment of the human intestine. This in vitro intestine model can be used to study drug absorption, localised gut inflammation and gut barrier integrity.

Lung-on-a-chip

Using CN Bio’s T12 plate with Transwell® inserts, researchers can create a Lung-on-a-chip system with lung epithelial cells that can be grown in a liquid-liquid or air-liquid interface. This allows inhaled compounds to be tested. Researchers can gather data on a compounds’ effect on lung cells and whether it can permeate through the epithelial lining in a system.

Human organ
mimics

Powerful new
data

Translatable
results

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+44 (0) 1223 737941
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