MPS-TL6 (Transwell^®-Liver) Consumable Plate

The PhysioMimix™ MPS-TL6 plate enables organ to organ crosstalk for multi-organ studies

More about the MPS-TL6 consumable plate

The MPS-TL6 plate enables true 2-organ communication between a Transwell^® and a Liver compartment in 6 independent wells, both with their own circular flow.

Each Transwell compartment accommodates standard 24-well plate 0.33 cm² Transwell^® inserts.

Each liver compartment contains an embedded three dimensional scaffold which facilitates the creation of a 3D liver microtissue from primary human hepatocytes (and non-parenchymal liver cells), that mimics the architecture and function of its in vivo counterpart.

Transwell^® and Liver compartments are linked together by an interconnect pump which enables independent recirculation of media from one compartment to the other to facilitate inter-organ crosstalk.

In conjunction with PhysioMimix OOC Multi-Organ System, the MPS-TL6 consumable plate can be used for a wide range of applications such as:

ADME
Pharmacokinetics/Pharmacodynamics (PK/PD)
Toxicology
Immune interactions

MPS-TL6 consumable plates are suitable for organoids, spheroids, iPSCs, primary cells, immortalized cell lines and commercial inserts (such as MucilAir^® or EpiSkin^®).

Liver

Gut

Lung

Skin

Kidney

In vitro to in vivo extrapolation using PBPK models

Liver compartment concentration: varying dose

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Gut apical concentration: varying dose

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Liver compartment concentration: varying liver clearance rate

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Combined with Physiologically-based Pharmacokinetic (PBPK) modelling, the PhysioMimix Multi-organ system and its MPS-TL6 consumable plate allow scientists to generate more translational datasets that more accurately represent a compound’s behaviour, ADME and toxicological profile.

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