This webinar details the current challenges in the field of integrating microphysiological systems with classic genetic toxicology.

It explores advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.

Watch this webinar to learn:

• Issues of current pre-clinical in vitro drug metabolism and genotoxicity tools and their low predictive power
• Obstacles to integrating novel microphysiological systems with classic genetic toxicology
• Recent advancements to successfully overcome these challenges

Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells.

The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials.

Speaker Information:

Dr Renato Cardoso

Scientific Director of Genetic Toxicology
Charles River Laboratories (Montreal – Canada)