Application of Microfluidic 3D Liver Chip Models To Genotoxicity Testing
Filed under: Genotoxicity and Safety toxicology
Video content if present
This webinar details the current challenges in the field of integrating microphysiological systems with classic genetic toxicology.
It explores advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.
Watch this webinar to learn:
Issues of current pre-clinical in vitro drug metabolism and genotoxicity tools and their low predictive power
Obstacles to integrating novel microphysiological systems with classic genetic toxicology
Recent advancements to successfully overcome these challenges
Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells.
The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials.
