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Chat live with an expert

Go with the Flow

October 9, 2020 by

Resource > Webinars >

Go with the Flow


Application of Microfluidic 3D Liver Chip Models To Genotoxicity Testing

Filed under: Genotoxicity and Safety toxicology

web s1e3 |

Video content if present

This webinar details the current challenges in the field of integrating microphysiological systems with classic genetic toxicology.


It explores advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.

Watch this webinar to learn:

  • Issues of current pre-clinical in vitro drug metabolism and genotoxicity tools and their low predictive power
  • Obstacles to integrating novel microphysiological systems with classic genetic toxicology
  • Recent advancements to successfully overcome these challenges

Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells.

The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials.


Speaker Information:

Dr Renato CardosoDr Renato Cardoso

Scientific Director of Genetic Toxicology
Charles River Laboratories (Montreal – Canada)

Video content if present

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