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Discover the applications


Investigate the validated core application areas that our PhysioMimix® products and services support

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Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
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Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
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ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
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Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

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icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix Core

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Consumables

Multi-chip plates
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Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Organ-on-a-Chip Resources

Featured

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Webinars

Building confidence for regulatory decision-making with immune competent models

Webinar Series 9 Episode 2

Discover how human liver models are building regulatory confidence in DILI risk assessment. How a continuously perfused, primary human Liver model, with immune-competent capabilities, can be leveraged to address a critical unmet need — capturing immune mediated toxicities associated with new drug modalities such as monoclonal antibodies (mAbs).

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Webinars

Building better data packages: The role of MPS in modern efficacy, toxicity and ADME workflows

Technology Network: Organoids and Microphysiological Systems Symposium 2026

Explores how MPS can be integrated into modern drug discovery workflows alongside other in vitro, in vivo and in silico tools to generate more predictive, human‑relevant data, improving translational confidence and informing decision making.

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Blogs

Integrating In Silico Tools with Organ-on-a-Chip to advance ADME studies

Knowing a drug’s bioavailability during lead optimization is crucial as it directly influences dosing strategy, therapeutic efficacy, safety margins, and formulation design.

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Scientific publications

Introduction to the 3RsC’s cross-platform microphysiological systems evaluation for drug-induced liver injury in collaboration with FDA-CDER

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Scientific publications

A microphysiological model of human MASLD reveals paradoxical response to resmetirom

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Scientific publications

Exploring the potential of liver MPS of varied configurations to model cholestatic chemical effects

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Scientific publications

Comparative analysis of species-specific hepatocyte function and drug effects in a liver microphysiological system PhysioMimix LC12 and 96-well plates

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Scientific publications

Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay

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Scientific publications

Human Liver MPS for Assessing Drug-Induced Liver Toxicity In Vitro

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Scientific publications

Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

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Scientific publications

Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation

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Scientific publications

Interconnected microphysiological systems for quantitative biology and phamarcology studies

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Scientific publications

Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins

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Scientific publications

Integrated assessment of diclofenac biotransformation, pharmacokinetics and omics-based toxicity in a 3D human liver-immunocompetent co-culture system

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Scientific publications

Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

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Latest news

  • CN Bio announces expert speaker line-up and scientific program for inaugural Organ-on-a-chip e-Symposium October 1, 2026
  • CN Bio awarded Innovate UK grant to reduce animal use in pharmacokinetic studies August 12, 2026
  • Organ-on-a-chip trends shaping the next phase of human-relevant R&D from the MPS World Summit 2026 July 6, 2026
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