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The Scars of Fat
The Transability of 3D NASH Microtissues To Model Human/murine NASH
Filed under: Disease modeling and NAFLD/NASH
Video content if present
This presentation aims to describe the unique role of one of the less studied members of the superfamily, the Bone Morphogenetic Protein 8b (BMP8B), in the pathophysiology of Non-Alcoholic Steatohepatitis (NASH).
Watch this Organ-on-a-chip webinar to learn:
- Discover how a high degree of translatability of the 3D NASH microtissues to model human/murine NASH is achieved.
- Learn about the potential of the 3D NASH microtissues as in vitro tools to study mechanistically TGFβ signalling.
- Hear how the NASH Assay can be used to reveal key mechanistic data underlying the human disease state to help develop new and better medicines.
Bone Morphogenetic Proteins (BMPs) are members of the TGFβ/BMP superfamily involved in the modulation of hepatic metabolism, liver regeneration, and in the progression of chronic liver disease toward fibrosis and hepatocellular carcinogenesis.
Dr Michele Vacca
Clinical Research Associate
Institute of Metabolic Science (TVP Lab, University of Cambridge)