• Skip to main content
  • Skip to footer
3Rs Collaborative-lead project with FDA
  • About us
  • News
  • Events
  • Careers
cn-bio-organ-on-a-chip-logo
  • Products
    • PhysioMimix® Core Microphysiological System
    • Consumables
      • PhysioMimix® Multi-chip plates
      • 3D validated cells
      • NASH-in-a-box
    • Organ-on-a-chip models
    • Gut/Liver-on-a-chip
    • Lung-on-a-chip
    • Support packages
  • Applications
    • Disease modeling
    • Safety toxicology
    • ADME
  • Services
    • Non-Alcoholic Steatohepatitis
    • Drug-Induced Liver Injury
    • ADME
  • Technology
  • Resources
  • Company
    • About us
    • Events
    • News
    • Careers in Biotech
  • Contact us

Explore our solutions


PhysioMimix® is a suite of hardware, consumables and assay protocols that enable you to recreate complex human biology and accurately predict human drug responses.

PhysioMimix Core

cnb1476_physiomimix-core_mark_mocks_system_v2
Learn more

Consumables

Multi-chip plates
3D validated cells
NASH-in-a-box
Bioavailability assay kit: Human 18
DILI assay kit: Human 24
Learn more

Models

Single-organ models
- Liver-on-a-chip model
- Lung-on-a-chip model
Multi-organ models
- Gut/Liver-on-a-chip models

Support packages

PhysioMimix® support packages

Discover the applications


Investigate the validated core application areas that our PhysioMimix® products and services support

Learn more

Disease modeling

Metabolic dysfunction-associated steatohepatitis
Hepatitis B
Pulmonary infection
Learn more

Safety toxicology

Drug-induced liver injury
Immune-mediated liver injury
Learn more

ADME

Drug absorption
Drug metabolism
Drug bioavailability
Oligonucleotide delivery
Learn more

Studies as a service


Our team will work collaboratively with you to design a study around your research goals and generate actionable data within weeks

Learn more
icon-nash-1-150x150.png MASLD/MASH
icon-dili-tox-150x150.png Drug-induced liver injury
icon-adme-150x150.png ADME

PhysioMimix® DILI assay kit: Human 24 for deeper mechanistic hepatotoxicity insights

April 10, 2025

Resource > Videos and animations >

PhysioMimix® DILI assay kit: Human 24 for deeper mechanistic hepatotoxicity insights

Filed under: DILI and Safety toxicology

cnb1384 dili assay vid v1 | Mechanistic hepatotoxicity

Video content if present

PhysioMimix® DILI assay kit: Human 24 for accurate DILI predictions and mechanistic hepatotoxicity insights

Drug-induced liver injury (DILI) is one of the leading causes of drug development failures, often emerging late in the drug development pipeline, when clinical trials are already underway. Traditional preclinical models struggle to predict complex, latent, and immune-related DILI mechanisms accurately, putting patients and investments at risk.

Gain deeper insights earlier in the process by utilizing the PhysioMimix DILI Assay Kit: Human 24. Leveraging our validated Liver-on-a-chip, it allows you to recreate our FDA-recognized DILI assay in your lab. This all-in-one kit enables you to effortlessly adopt Organ-on-a-chip technology and recreate human-relevant liver models with ease, providing a robust platform for evaluating complex and latent drug hepatotoxicity with greater accuracy.

Discover how the PhysioMimix DILI assay kit: Human 24:

  • Accurately predicts human-relevant DILI mechanisms, including immune-mediated toxicity
  • Reduces reliance on traditional in vitro and in vivo animal models that often fail to translate
  • Improve confidence in drug safety before progressing to clinical trials
  • Seamlessly integrate into your existing workflows for fast, reproducible results

To learn more, visit our PhysioMimix DILI assay kit: Human product page

Note. As of October 2025, PhysioMimix® OOC Systems mentioned in the video have been replaced by our universal PhysioMimix Core microphysiological system.

Video content if present

Speak to our experts

Request a meeting with one of our OOC experts to see how our products and services can support your studies

Request a meeting

Footer

CN Bio logo

332 Cambridge Science Park, Milton Road
Cambridge, CB4 0WN

UK: +44 (0) 1223 737 941

US: +1 415 523 4005

Privacy | Cookies | Regulatory | Accessibility
Website terms | Terms of sale

Product Recycling

©2025 CN Bio Innovations Ltd
Registered No. ‍06517359. VAT No. GB978184563

Latest news

  • UK plans to phase out animal testing faster in favor of alternative methods November 11, 2025
  • CN Bio launches all-in-one Organ-on-a-chip system, PhysioMimix® Core October 14, 2025
  • Regulatory Shifts and Validation: Key Insights from The World Congress on Alternatives and Animal Use in the Life Sciences Conference (WC13) September 30, 2025
Cyber Essentials Logo