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In vitro assessment of combination dosing regimen with in vivo-like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device

May 11, 2018 by

Resource > Posters >

In vitro assessment of combination dosing regimen with in vivo-like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device


American Associate for Cancer Research (AACR)

Filed under: ADME, Disease modeling, and Oncology

In vitro assessment of combination dosing regimens with in vivo like PK EDIT |
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Golby et al

The pharmacokinetic (PK) profile is a determining factor in both the safety and efficacy of a drug or therapeutic regimen. PK profiles can vary significantly between patients and between humans and pre-clinical animal species.​

Mouse Xenograft models are ubiquitous in oncology research, widely utilized to study single agents, combinations, and scheduling. Differences in PK between mice and humans are one factor limiting the translational relevance of xenograft studies. Additionally, studies to assess combinations and/or scheduling quickly require large numbers of animals owing to the many possible permutations. ​

Here we describe a device capable of recapitulating PK-like profiles in vitro and explore the effects of PK on the treatment of non-small-cell lung carcinoma by erlotinib alone and in combination with pemetrexed.

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  • The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system January 17, 2023
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