Publications

CN Bio publications in print

Systems Biology

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration

J Yu, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, DJ Hughes, DA Lauffenburger, LG Griffith, CL Stokes and M Cirit.
CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010. Epub 2015 Oct 5.

Disease Models

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

S E Wheeler, A M Clark, D P Taylor, C L Young, V C Pillai, D B Stolz, R Venkataramanan, D Lauffenburger, L Griffith, and A Wells
Br J Cancer. 2014 Dec 9; 111(12): 2342–2350.
Published online 2014 Oct 14. doi: 10.1038/bjc.2014.533

Long-term persistence of patient-derived hepatitis B virus infection in 3D microfluidic primary hepatocyte cultures

S.N. Wai, E. M. Large, D. Hughes, E. Sceats, M. Lussignol, M. T. Catanese, M. R. Thursz, M. Dorner.
Proceedings of the 65th Annual Liver Meeting (AASLD), 2014 Nov 7-11, Boston (MA), USA.

ADME/Tox/Metabolism

Quantitative assessment of population variability in hepatic drug metabolism using a perfused 3D human liver microphysiological system.

Nikolaos Tsamandouras, Tomasz Kostrzewski, Cynthia L Stokes, Linda G Griffith, David J Hughes and Murat Cirit.

Diclofenac metabolism and toxicity evaluation in a 3D-immune barrier liver bioreactor.

Ujjal Sarkar, Ravindra Kodihalli, Emma Large, Carissa L. Young, Dinelia Rivera-Burgos, Jiajie Yu1, Murat Cirit, David J. Hughes, John S. Wishnok, Douglas A. Lauffenburger, Linda G. Griffith, and Steven R. Tannenbaum.

Comparable toxicity of Acetaminophen and N-acetyl-meta-aminophenol in a perfused human 3D hepatocyte micro-tissue model.

Cliff Rowe, Mohsen Shaeri, Emma Large, Terri Cornforth, Angela Robinson, Bethany McCloskey, Rowena Sisson-Young, Ian Copple, Christopher Goldring, David Hughes.

3D microfluidic bioartificial liver cultures recapitulate the complete life cycle of hepatitis B virus, hepatitis C virus and malaria

Sann Nu Wai, Ana Maria Ortega-Prieto, Emma Large, Marion Lussignol, Fiona Angrisano, Andrew M. Blagborough, Gema Vizcay, David Hughes, Mark Thursz, Roland Fleck, Jacob Baum, Maria Teresa Catanese and Marcus Dorner

Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Ujjal Sarkar, Dinelia Rivera-Burgos, Emma M. Large, David J. Hughes, Kodihalli C. Ravindra, Rachel L. Dyer, Mohammad R. Ebrahimkhani, John S. Wishnok, Linda G. Griffith and Steven R. Tannenbaum.
Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29.

Platform

Bioreactor technologies to support liver function in vitro

Mohammad R. Ebrahimkhani , Jaclyn A. Shepard Neiman , Micha Sam B. Raredon , David J. Hughes , Linda G. Griffith

Bioreactor technologies to support liver function in vitro. Adv Drug Deliv Rev 69-70, 132-157 (2014).

Tissue engineering: Organs from the lab

Vivien Marx.
Nature 522, 373–377 (18 June 2015) doi:10.1038/522373a, Published online 17 June 2015

Perfused multiwell plate for 3D liver tissue engineering.

Domansky K, Inman W, Serdy J, Dash A, Lim MH, Griffith LG.
Lab Chip. 2010 Jan 7;10(1):51-8. doi: 10.1039/b913221j. Epub 2009 Oct 22.

Liver tissue engineering in the evaluation of drug safety.

Dash A, Inman W, Hoffmaster K, Sevidal S, Kelly J, Obach RS, Griffith LG, Tannenbaum SR.
Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1159-74. doi: 10.1517/17425250903160664.

Industry publications in print

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